Comparing saline and chlorhexidine for wound irrigation after cesarean delivery
Wound Irrigation With Saline Versus Hypodilute-chlorhexidine After Cesarean Section: a Randomized Clinical Trial (WISHES Study)
This study is testing whether using saline or a special antiseptic solution helps wounds heal better after a cesarean delivery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Loma Linda University Academic / other |
| Locations | 1 site (Loma Linda, California) |
| Trial ID | NCT06339203 on ClinicalTrials.gov |
What this trial studies
This clinical trial compares the effects of normal saline and a low concentration of Chlorhexidine Gluconate (Irrisept) for wound irrigation in patients who have undergone cesarean delivery. It is an open-label, randomized controlled trial designed to assess postoperative wound healing outcomes. The study will enroll participants who meet specific eligibility criteria, including age and certain medical complications, and will be conducted at Loma Linda University Children's Hospital.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 or older, undergoing planned cesarean deliveries with specific medical complications.
Not a fit: Patients undergoing emergency cesarean deliveries will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve postoperative wound healing and reduce infection rates in cesarean delivery patients.
How similar studies have performed: Other studies have explored similar irrigation techniques, but this specific comparison of saline versus low-concentration chlorhexidine is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 or older * Singleton pregnancy * Planned cesarean delivery at gestational age 37 weeks or later at Loma Linda University Children's Hospital * Planned post-operative follow up with Loma Linda OBGYN * Speak English or Spanish * At least one of the following medical complications: Obesity BMI\>= 30kg/m2, Diabetes, Spontaneous rupture of membranes, Intraamniotic infection Exclusion Criteria: * Emergency cesarean delivery
Where this trial is running
Loma Linda, California
- Loma Linda University — Loma Linda, California, United States (Recruiting)
Study contacts
- Principal investigator: Ruofan Yao, MD, MPH — Loma Linda University
- Study coordinator: Nikia Gray-Hutto, AS
- Email: nhutto@llu.edu
- Phone: 9095584000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.