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Comparing robotic and video-assisted surgery for lung cancer

Robot-Assisted Versus Video-Assisted Lobectomy for Non-Small Cell Lung Cancer (RAVAR): A Multicenter, Open-Label, Randomized, Non-Inferiority Trial

Not applicable Interventional Sun Yat-sen University · NCT06524427

This study is testing whether robot-assisted surgery is better than video-assisted surgery for people with early-stage lung cancer.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment1124 (estimated)
Ages18 Years to 80 Years
SexAll
SponsorSun Yat-sen University Academic / other
Drugs / interventionschemotherapy, immunotherapy
Locations23 sites (Chongqing, Chongqing Municipality and 22 other locations)
Trial IDNCT06524427 on ClinicalTrials.gov

What this trial studies

This clinical trial compares the outcomes of robot-assisted thoracoscopic surgery (RATS) and video-assisted thoracoscopic surgery (VATS) in patients with early-stage non-small cell lung cancer (NSCLC). It is a multicenter, prospective randomized controlled trial focusing on patients diagnosed with stage I-II NSCLC. The primary endpoint is the 5-year disease-free survival (DFS) rate, allowing researchers to evaluate both short-term and long-term surgical outcomes. The study aims to address existing scientific questions regarding the effectiveness of RATS compared to VATS.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 80 with stage I-II non-small cell lung cancer and adequate organ function.

Not a fit: Patients with advanced-stage lung cancer or those with significant comorbidities may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide insights into which surgical approach offers better outcomes for patients with early-stage lung cancer.

How similar studies have performed: Previous studies have shown promising results for robotic-assisted surgeries, but this specific comparison with VATS is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Age from 18 to 80 years old;
2. Patients with blood pressure\<160/100mmHg, 5.6\<blood glucose\<11.2mmol/L, major organs function normally: (1) Goldman index between grade 1 and 2; (2) Predicted forced expiratory volume in 1s (FEV1) \>= 40 % and diffusing capacity of the lung for carbon monoxide (DLCO) \>= 40 %; (3) total bilirubin \<= 1.5 upper limit of normal; (4) Alanine aminotransferase (ALT)/Aspartate aminotransferase (AST) \<= 2.5 upper limit of normal; (5) creatinine \<= 1.25 upper limit of normal and creatinine clearance rate (CCr) \>= 60ml/min;
3. The first clinical diagnosis before surgery was non-small cell lung cancer, including adenocarcinoma, squamous cell carcinoma, large cell carcinoma, and other unknown types;
4. Clinical stage T1-2N0-1 (cI-II): Maximum diameter of tumor \<= 5cm and short diameter of mediastinal lymph node \<= 1cm in thin layer CT;
5. Performance status of Eastern Cooperative Oncology Group (ECOG) 0-1;
6. All relevant examinations were completed within 28 days before the operation;
7. Patients who understand this study and have signed an approved Informed Consent.

Exclusion Criteria:

1. Patients with radiotherapy, chemotherapy, targeted therapy, or immunotherapy before surgery.
2. Patients with the previous history of other malignancies;
3. Patients with secondary primary cancer when enrolled;
4. Patients diagnosed as pure ground glass opacity (GGO) before surgery;
5. Patients diagnosed as mixed GGO whose solid part \<= 50% and Maximum diameter of tumor \<= 2cm;
6. Patients with small cell lung cancer;
7. Patients with prior unilateral open thoracic surgical procedures;
8. Woman who is pregnant or breastfeeding;
9. Patients with interstitial pneumonia, pulmonary fibrosis, or severe emphysema;
10. Patients with an active bacterial or fungal infection that is difficult to control;
11. Patients with serious psychosis;
12. Patients with a history of severe heart attack, heart failure, myocardial infarction, or angina within the last 6 months.

Where this trial is running

Chongqing, Chongqing Municipality and 22 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Non Small Cell Lung CancerNon-small cell lung cancerRobotic-assisted lobectomyVideo-assisted lobectomy
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.