Comparing recovery times of half dose sugammadex and neostigmine after surgery
Official title: Comparison of Recovery Times Between 1 mg/kg Sugammadex and 60 mcg/kg Neostigmine for Moderate Neuromuscular Blockade Induced by Rocuronium in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Trial
Run by Universitas Padjadjaran · NCT06794450 · Data updated 2026-11-12
This study is testing whether a half dose of sugammadex works better than neostigmine to help people recover faster from anesthesia after gallbladder surgery.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 59 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Universitas Padjadjaran Academic / other |
| Locations | 1 site (Bandung, West Java) |
| Status | Recruiting |
| Started | November 5, 2024 |
| Main results expected | February 2025 |
| Study ends | February 2025 |
| Registry record updated | January 28, 2025 |
| Trial ID | NCT06794450 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18-59 who have undergone laparoscopic cholecystectomy with the use of rocuronium.
✕Probably not a fit
Patients with a history of drug allergies to the agents used, renal dysfunction, musculoskeletal disorders, central nervous system disorders, or difficult airways may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study compares the effectiveness of half dose sugammadex and neostigmine in reversing the effects of rocuronium, a neuromuscular blocking agent, used during laparoscopic cholecystectomy under general anesthesia. Participants will receive either sugammadex or neostigmine after surgery to evaluate which agent provides a faster and more predictable recovery time from neuromuscular blockade. The study aims to address the limitations of neostigmine's indirect action and the high cost of sugammadex by investigating a lower dose of the latter. The findings could lead to improved postoperative outcomes and reduced complications associated with residual neuromuscular blockade.
Why it matters
Potential benefit: If successful, this study could provide a more effective and cost-efficient method for reversing neuromuscular blockade, leading to quicker recovery times for patients.
How similar studies have gone: While the use of sugammadex has been studied, this specific comparison with half doses against neostigmine is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who underwent laparoscopic cholecystectomy under general anesthesia * Using muscle relaxant rocuronium * Aged 18-59 years * American Society of Anesthesiologists (ASA) physical status classification of 1 or 2. Exclusion Criteria: * History of drug allergies to the agents used * Renal dysfunction * Musculoskeletal disorders * Central nervous system disorders * Difficult airways requiring intubation without the use of muscle relaxants.
Where it's running
-
Hasan Sadikin General Hospital
Bandung, West Java, Indonesia Recruiting
Study contacts
- Study coordinator: Rivan P Rivan Putra Afewa, M.D., M.D.
- Email: rivan.chaniago@gmail.com
- Phone: +6285316832464
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.