Comparing Ramosetron and Loperamide for treating Low Anterior Resection Syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the safety and efficacy of Ramosetron, a 5-HT3 receptor antagonist, compared to Loperamide for patients suffering from Low Anterior Resection Syndrome (LARS) following rectal cancer surgery. It is a multicenter randomized controlled trial aimed at determining which treatment provides better symptom relief for patients experiencing major LARS. Participants will be recruited from Seoul National University Hospital and will be monitored for their response to the interventions over a specified period post-surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* mid and low rectal cancer (AV\<15cm)
* stage II, III, preop long-course CCRT, then ileostomy repair
* about 1\~12 months after operation (no stomy)
* about 1\~6 months after ileostomy repair
* major LARS

Exclusion Criteria:

* recurred rectal cancer
* stage IV
* IBD
* uncontrolled preoperative fecal incontinence or constipation

Where it's running

• Seoul National University Hospital
  Seoul, Jongro-gu, South Korea Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  We will test whether an intensified follow-up program can reduce LARS symptoms and improve quality of life for people who have had rectal cancer surgery with a protective ileostomy.

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• Assessing the effectiveness of low volume transanal irrigation for patients with Low Anterior Resection Syndrome

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.