Comparing radiofrequency and cryoablation techniques for treating atrial fibrillation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of two interventional methods, radiofrequency ablation and cryoablation, in treating patients with persistent and long-term atrial fibrillation (AF). Atrial fibrillation is a significant risk factor for stroke, and this research seeks to identify predictors of recurrence in patients who have not responded to antiarrhythmic therapy. By comparing these two techniques, the study hopes to improve treatment outcomes for individuals suffering from AF and reduce the associated risks of stroke and disability.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age over 18 years old;
* Atrial fibrillation resistant to antiarrhythmic therapy;
* Persistent and long-persisting form of atrial fibrillation;
* The patient's consent to participate in the study.

Exclusion Criteria:

* Age under 18 and over 80 years old;
* The presence of another cardiac pathology requiring surgical treatment;
* Congenital heart defects;
* Previous "open" cardiac surgery;
* Bone marrow diseases;
* Pathology of the blood coagulation system;
* The left ventricular ejection fraction is less than 40%;
* Moderate to severe renal insufficiency (creatinine clearance \<50 ml/min);
* Drug-resistant hypertension (despite hypotensive therapy);
* Organically altered mitral valve;
* There are reasons to assume that the patient will not show up for subsequent visits (control points of the study) for various reasons;
* The patient's participation in another clinical trial.

Where it's running

• Bakulev National Medical Research Center for Cardiovascular Surgery
  Moscow, Russia Recruiting

Study contacts

• Principal investigator: Andrey Filatov — Bakulev Scientific Center for Cardiovascular Surgery
• Study coordinator: Andrey Filatov
• Email: agfilatov@bakulev.ru
• Phone: +7(495) 414-77-02

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Very high-power short-duration vs standard low-power radiofrequency ablation for atrial fibrillation

  This trial tests whether very high-power short-duration ablation (90 W) is as safe and more effective than conventional low-power ablation (35-45 W) for treating atrial fibrillation.

  Recruiting Bakulev Scientific Center of Cardiovascular Surgery · Moscow · NCT07728539

• AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

  This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.

  Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Leuven and 6 other locations · NCT07924371

• Rural Telemedicine-Enabled Care to Prevent Stroke in Older Adults in China

  A telemedicine-supported care model led by rural doctors will be tested to see if it can reduce stroke and heart problems in adults 65+ living in rural China.

  Recruiting at 2 sites Jiangsu Province (Suqian) Hospital · Suqian, Jiangsu and 1 other locations · NCT07628283

• Deep phenotyping to explore recovery in young adults after stroke

  This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.

  Recruiting The Florey Institute of Neuroscience and Mental Health · Heidelberg, Victoria and 1 other locations · NCT07019493

• Stem cell therapy for chronic stroke recovery

  This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.

  Recruiting Phase 2 Hokkaido University Hospital · Sapporo, Hokkaido · NCT06752720

• Using a new imaging agent to detect inflamed plaque in heart and brain patients

  This study is testing a new imaging agent to see if it can help spot inflamed plaque in patients who have recently had a heart attack or stroke.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06091319

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.