Comparing PRP, PRF, and standard treatment for chronic skin ulcers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of two newer treatments, platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), in comparison to conventional methods for managing chronic non-healing skin ulcers. Chronic ulcers are defined as wounds that do not heal within six weeks despite appropriate treatment, affecting millions of individuals, particularly the elderly and diabetic populations. The study will involve patients with ulcers of varying sizes and durations, assessing the healing outcomes of the different treatment modalities. The interventions will include surgical debridement, normal saline washing, and dressing coverage alongside the experimental treatments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients presenting with cutaneous ulcers greater than six weeks of duration and a size ranging between 0.5 and 10 cm, having a normal platelet count and hemoglobin \>10 gm%.

Exclusion Criteria:

* Patients with known bleeding disorders, and/or on oral anticoagulant therapy, uncontrolled diabetes, proven malignancy.
* Patients who are pregnant or lactating.
* Patients with actively infected ulcers, clinically defined by purulent discharge, green discoloration or fever, or positive culture, ulcers with exposed bone with no underlying granulation tissue, HIV, HCV, HBV patients.
* Patients who are with unrealistic expectations and unwilling to give consent for treatment or photography.

Where it's running

• Badr Hospital - Helwan University and Kafrelseikh University Hospital
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Mohamed Aboshabana Hussein, Assistant Lecturer
• Email: dr.mohamedaboshabana@gmail.com
• Phone: 01007981008

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.