Comparing proton and photon radiation for treating retroperitoneal sarcomas

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the safety and appropriate dosing of proton beam radiation therapy and intensity-modulated radiation therapy (IMRT) for patients with retroperitoneal sarcomas. Participants will receive radiation therapy daily for about six weeks before undergoing surgery to remove their tumors. The study aims to minimize damage to normal tissue while effectively targeting the tumors. Additionally, blood samples may be collected for further genomic analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Histologically proven primary soft tissue sarcoma of the retroperitoneum
* Measurable disease
* Life expectancy of greater than 2 years

Exclusion Criteria:

* Prior radiation therapy for retroperitoneal sarcoma
* Pregnant or breastfeeding
* Chemotherapy within 4 weeks prior to entering study
* Receiving other investigational agents
* Other types of sarcomas
* Multifocal disease, lymph node or distant metastases
* History of sensitivity to radiation therapy
* Uncontrolled intercurrent illness
* History of a different invasive malignancy within the past 3 years
* HIV positive on combination anti-retroviral therapy

Where it's running

• Rush University Medical Center
  Chicago, Illinois, United States Recruiting
• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting
• Dana-Farber Cancer Institute
  Boston, Massachusetts, United States Recruiting
• Mayo Clinic
  Rochester, Minnesota, United States Recruiting
• Washington University School of Medicine Siteman Cancer Center West County
  Creve Coeur, Missouri, United States Recruiting
• Washington University School of Medicine Siteman Cancer Center South County
  St Louis, Missouri, United States Recruiting

Study contacts

• Principal investigator: Thomas F. DeLaney, M.D. — Massachusetts General Hospital
• Study coordinator: Thomas DeLaney, MD
• Email: tdelaney@partners.org
• Phone: 617-726-6876

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Personalised neoadjuvant therapy planning for adults with high‑risk soft tissue sarcoma

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• Assessing colorectal resections in patients with retroperitoneal sarcoma

  This study is trying to see how different surgical techniques for removing retroperitoneal sarcomas affect patients' recovery and quality of life.

  Recruiting at 16 sites Heidelberg University · Mannheim, Baden-Wurttemberg and 15 other locations · NCT06943612

• Short course radiation treatment for retroperitoneal sarcoma before surgery

  This study is testing a shorter radiation treatment for patients with retroperitoneal sarcoma to see if it can be safely used before surgery.

  Recruiting Phase 1 Brigham and Women's Hospital · Boston, Massachusetts · NCT06812052

• Electrochemotherapy for unresectable visceral tumors including liver metastases

  This will try electrochemotherapy with bleomycin in adults who have unresectable primary or metastatic visceral tumors, such as liver metastases.

  Recruiting Istituto Oncologico Veneto IRCCS · Padova · NCT06753136

• Proton therapy combined with standard radiation for treating retroperitoneal sarcoma

  This study is testing a new type of radiation therapy combined with standard treatment to see if it helps people with newly diagnosed retroperitoneal sarcoma before they have surgery.

  Recruiting Phase 1/2 Northwestern University · Chicago, Illinois · NCT06327477

• Using Abemaciclib and Radiation Therapy Before Surgery for High-Risk Retroperitoneal Sarcoma

  This study is testing if taking a medication called abemaciclib along with radiation therapy before surgery can help shrink tumors in patients with high-risk retroperitoneal sarcoma.

  Recruiting Phase 1 University of Washington · Seattle, Washington · NCT06025747

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.