Comparing Propofol and Sevoflurane for Managing Erections During Urological Surgery
Official title: Prospective, Randomized-Controlled Study of the Effect of Propofol vs. Sevoflurane on Erections During Narcosis in Transurethral Surgery
Run by University of Zurich · NCT06378645 · Data updated 2026-11-12
This study is testing whether using propofol or sevoflurane as anesthesia during urological surgery affects the chances of having unwanted erections and if it leads to more complications for patients.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 75 Years |
| Sex | Men only |
| Enrollment | 200 (estimated) |
| Sponsor | University of Zurich Academic / other |
| Locations | 1 site (Zurich) |
| Status | Recruiting |
| Started | February 1, 2024 |
| Main results expected | December 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | April 22, 2024 |
| Trial ID | NCT06378645 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult males scheduled for transurethral surgery with a preoperative IIEF-5 score of 12 or higher.
✕Probably not a fit
Patients with contraindications to propofol or sevoflurane, or those unable to provide informed consent, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of two anesthetic agents, propofol and sevoflurane, on the occurrence of unwanted penile erections during transurethral surgeries. It aims to determine whether the use of propofol, which has been associated with a higher incidence of intraoperative erections, leads to more complications compared to sevoflurane. The research will involve patients scheduled for transurethral operations, assessing their experiences and outcomes based on the type of anesthesia used. The study is crucial as it addresses a gap in existing literature regarding the impact of anesthesia on intraoperative events.
Why it matters
Potential benefit: If successful, this study could lead to improved anesthesia protocols that minimize unwanted intraoperative erections, enhancing surgical outcomes and patient comfort.
How similar studies have gone: While there is limited high-quality evidence on this topic, previous studies have indicated varying rates of intraoperative erections with different anesthetic agents, suggesting that this area warrants further investigation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Planned transurethral operation in the department of urology. * Preoperative IIEF-5 Score ≥12 * Planned surgery time ≥15min Exclusion Criteria: * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant. * Inability to provide informed consent. * Contraindications to Propofol or Sevoflurane, e.g. known hypersensitivity or allergy. * Known or suspected non-compliance, drug or alcohol abuse. * Participation in another study with an investigational drug within the 30 days preceding and during the present study. * Previous enrolment into the current study. * Enrolment of the investigator, his/her family members, employees and other dependent persons.
Where it's running
-
University Hospital Zurich
Zurich, Switzerland Recruiting
Study contacts
- Principal investigator: Etienne X Keller, Ass Prof, MD — University Hospital Zurich, University of Zurich
- Study coordinator: Etienne X Keller, Ass Prof, MD
- Email: EtienneXavier.Keller@usz.ch
- Phone: +41 44 255 54 40
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.