Comparing Propofol and Sevoflurane Anesthesia for Liver Tumor Surgery
Impact of Propofol-Based Total Intravenous Anesthesia Versus Anesthesia With Sevoflurane
This study is testing whether using propofol or sevoflurane for anesthesia during liver tumor surgery helps people with liver cancer recover better and live longer.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 500 (estimated) |
| Ages | 20 Years to 80 Years |
| Sex | All |
| Sponsor | Kaohsiung Medical University Chung-Ho Memorial Hospital Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Kaohsiung City) |
| Trial ID | NCT05331911 on ClinicalTrials.gov |
What this trial studies
This clinical trial is a two-arm, parallel-group randomized trial that aims to evaluate the long-term outcomes of patients undergoing elective partial hepatectomy for primary liver tumors. Approximately 500 volunteers with hepatocellular carcinoma will be randomly assigned to receive either propofol or sevoflurane for anesthesia maintenance during surgery. The study will monitor various parameters, including overall survival and progression-free survival, as well as postoperative complications and functional capacity. Data will be collected on anesthetic drug dosages, patient demographics, and surgical outcomes to determine the effectiveness of each anesthesia method.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged 20 to 80 years with ASA class I-III who are scheduled for elective partial hepatectomy due to hepatocellular carcinoma.
Not a fit: Patients with severe mental disorders, morbid obesity, or those undergoing emergency surgery will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into which anesthesia method leads to better long-term survival outcomes for patients undergoing liver tumor surgery.
How similar studies have performed: Other studies have explored anesthesia methods in surgical settings, but this specific comparison of propofol versus sevoflurane in liver surgery is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Twenty to eighty-year-old. 2. ASA class I-III. 3. Patients undergoing partial hepatectomy for hepatocellular carcinoma under general anesthesia. Exclusion Criteria: 1. Severe mental disorder 2. Pregnant or lactating women 3. Morbidly obese 4. Allergy to any of the drugs used in this study 5. Recurrent tumor or repeat surgery 6. Biopsy cases 7. Incomplete data collection before the surgery 8. Palliative treatment after surgery 9. simultaneous treatment of other malignancies 10. Combined propofol and inhalation anesthesia or other anesthetics, such as ketamine or dexmedetomidine 11. Diagnosed as benign liver tumor 12. Emergency surgery
Where this trial is running
Kaohsiung City
- Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan (Recruiting)
Study contacts
- Study coordinator: Guan-Yu Chen, M.D.
- Email: kindtaco@gmail.com
- Phone: 07-3121101
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.