Comparing Propofol and Sevoflurane Anesthesia for Liver Tumor Surgery
Official title: Impact of Propofol-Based Total Intravenous Anesthesia Versus Anesthesia With Sevoflurane
Run by Kaohsiung Medical University Chung-Ho Memorial Hospital · NCT05331911 · Data updated 2026-11-12
This study is testing whether using propofol or sevoflurane for anesthesia during liver tumor surgery helps people with liver cancer recover better and live longer.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 20 Years to 80 Years |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Kaohsiung Medical University Chung-Ho Memorial Hospital Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Kaohsiung City) |
| Status | Recruiting |
| Started | April 26, 2022 |
| Main results expected | December 31, 2026 |
| Study ends | March 31, 2027 |
| Registry record updated | November 30, 2022 |
| Trial ID | NCT05331911 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients aged 20 to 80 years with ASA class I-III who are scheduled for elective partial hepatectomy due to hepatocellular carcinoma.
✕Probably not a fit
Patients with severe mental disorders, morbid obesity, or those undergoing emergency surgery will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial is a two-arm, parallel-group randomized trial that aims to evaluate the long-term outcomes of patients undergoing elective partial hepatectomy for primary liver tumors. Approximately 500 volunteers with hepatocellular carcinoma will be randomly assigned to receive either propofol or sevoflurane for anesthesia maintenance during surgery. The study will monitor various parameters, including overall survival and progression-free survival, as well as postoperative complications and functional capacity. Data will be collected on anesthetic drug dosages, patient demographics, and surgical outcomes to determine the effectiveness of each anesthesia method.
Why it matters
Potential benefit: If successful, this study could provide insights into which anesthesia method leads to better long-term survival outcomes for patients undergoing liver tumor surgery.
How similar studies have gone: Other studies have explored anesthesia methods in surgical settings, but this specific comparison of propofol versus sevoflurane in liver surgery is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Twenty to eighty-year-old. 2. ASA class I-III. 3. Patients undergoing partial hepatectomy for hepatocellular carcinoma under general anesthesia. Exclusion Criteria: 1. Severe mental disorder 2. Pregnant or lactating women 3. Morbidly obese 4. Allergy to any of the drugs used in this study 5. Recurrent tumor or repeat surgery 6. Biopsy cases 7. Incomplete data collection before the surgery 8. Palliative treatment after surgery 9. simultaneous treatment of other malignancies 10. Combined propofol and inhalation anesthesia or other anesthetics, such as ketamine or dexmedetomidine 11. Diagnosed as benign liver tumor 12. Emergency surgery
Where it's running
-
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan Recruiting
Study contacts
- Study coordinator: Guan-Yu Chen, M.D.
- Email: kindtaco@gmail.com
- Phone: 07-3121101
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.