Comparing Propofol and Dexmedetomidine for Reducing Postoperative Nausea and Vomiting

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares the effectiveness of propofol infusion versus dexmedetomidine infusion in reducing the incidence of postoperative nausea and vomiting (PONV) in patients undergoing ureteroscopic procedures under spinal anesthesia. It focuses on patients aged 18 to 60 years who have multiple risk factors for PONV, such as being female, having a history of PONV, and being non-smokers. The study aims to understand the mechanisms by which these medications may alleviate nausea and vomiting post-surgery, considering the physiological effects of regional anesthesia on the body. By analyzing the outcomes, the study seeks to improve patient recovery experiences and satisfaction.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 18 to 60 years
* ASA physical status I-II
* Scheduled for ureteroscopic procedure
* With more than one Risk factor for PONV (female, history of PONV, non-smoking).

Exclusion Criteria:

* Patients with contraindications for spinal anesthesia including infection at the injection site, bleeding diathesis, known left ventricular outflow obstruction, hypovolemia, and increased intracranial pressure.
* History of allergy or hypersensitivity to propofol or dexmedetomidine.
* Gastrointestinal diseases e.g. gastroenteritis and gastric ulcers, ear diseases e.g. infections of middle and inner ear, liver cirrhosis.
* Those who have received antiemetic drugs within 48 hours before surgery.
* Operations lasting more than two hours.
* The patient's unwillingness.

Where it's running

• Kasralaini Medical School
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Beshoy Atef
• Email: beshoyatef01@gmail.com
• Phone: 01220703346

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.