Comparing Portal Pressure Measurements in Different Positions
The Comparative Study on Left Lateral Position and Supine Position in Endoscopic Ultrasound Guided Portal Pressure Gradient Measurement
This study is testing whether measuring portal pressure in different positions helps people with liver cirrhosis and varices get more accurate results.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Hangzhou) |
| Trial ID | NCT06994039 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the correlation between portal pressure gradient measurements obtained through endoscopic ultrasound in two different positions: supine and left lateral decubitus. The study focuses on patients with liver cirrhosis and esophagogastric varices, addressing the limitations of the traditional hepatic venous pressure gradient measurement. By comparing the consistency of EUS-PPG measurements in these positions, the study seeks to determine if one position offers more reliable results than the other. The findings could enhance the clinical application of EUS-PPG in assessing portal hypertension.
Who should consider this trial
Good fit: Ideal candidates for this study are hospitalized patients with liver cirrhosis complicated by esophagogastric varices who are willing to consent to the procedure.
Not a fit: Patients with uncorrectable coagulopathy, thrombocytopenia, bacteremia, or those who are pregnant or outside the age range of 18 to 81 may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the accuracy and reliability of portal pressure measurements, leading to better management of patients with liver cirrhosis and varices.
How similar studies have performed: While EUS-PPG has shown promise in previous studies, the specific comparison of measurements in different positions is less explored, making this approach somewhat novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The gastroesophageal variceal patients hospitalized for endoscopic therapy, and are willing to sign the informed consent of measuring portal vein pressure gradient under endocsopic ultrasound. Exclusion Criteria: * （1）unwilling to sign the informed consent （2）uncorrectable coagulopathy (INR\>1.5) （3）uncorrectable thrombocytopenia (platelets \<20,000/μL) （4）Bacteremia （5）Age\<18,or≥81 （6）pregnancy
Where this trial is running
Hangzhou
- The 2nd Affiliated Hospital, School of Medicine, Zhejiang University — Hangzhou, China (Recruiting)
Study contacts
- Study coordinator: Meng Xue, PhD
- Email: xuemeng@zju.edu.cn
- Phone: 8613958123617
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.