Comparing pain responses in Parkinson's patients and healthy individuals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare pain intensity and discomfort levels between patients with Parkinson's disease and healthy controls during the induction of mechanical, thermal, and chemical experimental pain. Participants will include healthy volunteers, patients with Parkinson's disease receiving levodopa treatment, and those with deep brain stimulation treatment. The study will involve a randomized design where each participant undergoes a test session lasting approximately 1.5 hours at the Department of Neurophysiology, Aarhus University Hospital. The research will utilize a power calculation to ensure adequate sample size for statistical analysis.

Why it matters

Who can join: the full rules

Inclusion criteria

* Group healthy volunteers: healthy subjects with no PD diagnosis
* Group PD patients levodopa: Include PD patients treated with levodopa
* Group PD patients DBS: Include PD patients with DBS Exclusion criteria
* Known other neurological or medical disorders (e.g., stroke, neuropathy, diabetes) or other disorders with expected influence on experimental pain
* Known dementia (a score \<24 on the MoCA)
* Known untreated depression (a score ≥15 on the Beck Depression Inventory)
* Unable to cooperate
* Treated with painkillers except paracetamol and NSAID (except if pain and treatment is ad-equately stable as evaluated by a doctor)

Where it's running

• aarhus university Hospital
  Aarhus, Denmark Recruiting

Study contacts

• Study coordinator: Andrea Søndergaard Poulsen, PhD student
• Email: andrea-s-p@hotmail.com
• Phone: +4561110138

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.