Comparing pain responses in Parkinson's patients and healthy individuals
Comparing Pain Intensity and Discomfort in Patients With Parkinson´s Disease and Healthy Controls During Inducement of Mechanical, Thermal, and Chemical Experimental Pain
This study is trying to see how pain feels different for people with Parkinson's disease compared to healthy individuals when they experience various types of pain.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 63 (estimated) |
| Sex | All |
| Sponsor | University of Aarhus Academic / other |
| Locations | 1 site (Aarhus) |
| Trial ID | NCT05981261 on ClinicalTrials.gov |
What this trial studies
This study aims to compare pain intensity and discomfort levels between patients with Parkinson's disease and healthy controls during the induction of mechanical, thermal, and chemical experimental pain. Participants will include healthy volunteers, patients with Parkinson's disease receiving levodopa treatment, and those with deep brain stimulation treatment. The study will involve a randomized design where each participant undergoes a test session lasting approximately 1.5 hours at the Department of Neurophysiology, Aarhus University Hospital. The research will utilize a power calculation to ensure adequate sample size for statistical analysis.
Who should consider this trial
Good fit: Ideal candidates include healthy individuals and patients with Parkinson's disease who are either on levodopa treatment or have undergone deep brain stimulation.
Not a fit: Patients with other neurological disorders, untreated depression, or those unable to cooperate may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of pain mechanisms in Parkinson's disease, potentially leading to improved pain management strategies for patients.
How similar studies have performed: While this approach is novel in the context of Parkinson's disease, similar studies have shown success in understanding pain responses in other conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria * Group healthy volunteers: healthy subjects with no PD diagnosis * Group PD patients levodopa: Include PD patients treated with levodopa * Group PD patients DBS: Include PD patients with DBS Exclusion criteria * Known other neurological or medical disorders (e.g., stroke, neuropathy, diabetes) or other disorders with expected influence on experimental pain * Known dementia (a score \<24 on the MoCA) * Known untreated depression (a score ≥15 on the Beck Depression Inventory) * Unable to cooperate * Treated with painkillers except paracetamol and NSAID (except if pain and treatment is ad-equately stable as evaluated by a doctor)
Where this trial is running
Aarhus
- aarhus university Hospital — Aarhus, Denmark (Recruiting)
Study contacts
- Study coordinator: Andrea Søndergaard Poulsen, PhD student
- Email: andrea-s-p@hotmail.com
- Phone: +4561110138
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.