Comparing pain relief methods in knee replacement surgery
Comparison of Outcomes Between Multimodal Intraosseous Femoral Injection and Multimodal Intraosseous Tibial Injection, a Randomized Controlled Trial in Simultaneous Bilateral Total Knee Arthroplasty Patients
This study tests which of two pain relief methods, femoral or tibial injections, works better for people having knee replacement surgery to help them feel better and recover faster.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 55 Years and up |
| Sex | All |
| Sponsor | Department of Medical Services Ministry of Public Health of Thailand Government |
| Locations | 1 site (Phaya Thai, Bangkok) |
| Trial ID | NCT06243575 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of two different intraosseous injection techniques, femoral and tibial, for managing postoperative pain in patients undergoing simultaneous bilateral total knee arthroplasty due to osteoarthritis. The goal is to determine which method provides better pain relief and improves patient outcomes, potentially reducing hospital stay. Participants will receive either the femoral or tibial injection as part of their pain management protocol following surgery.
Who should consider this trial
Good fit: Ideal candidates are patients scheduled for bilateral total knee replacement surgery due to osteoarthritis.
Not a fit: Patients with a history of knee or hip surgery, or those with certain medical conditions such as chronic kidney or liver disease, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing knee replacement surgery.
How similar studies have performed: While studies have shown the effectiveness of periarticular injections for pain relief, this specific comparison of femoral versus tibial injections in simultaneous bilateral TKA is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who will undergo bilateral Total knee Replacement due to osteoarthritis of both knees * Used of a cemented, PS design TKA surgery. * Able to give informed consent Exclusion Criteria: * Revision TKA * History of previous knee or hip surgery * History of allergic reaction or side effects to the drug that will be used in the experiment * Underlying diseases of chronic kidney disease or chronic liver disease (Child Pugh B or C) * Pregnancy * History of coagulopathy or abnormal blood coagulation profile(INR \>1.4 or aPTT ratio \> 1.4) * History of platelet dysfunction or platelet count \< 140,0000/mm3 * History of Thromboembolism * Use of Anticoagulants.
Where this trial is running
Phaya Thai, Bangkok
- Rajavithi hospital — Phaya Thai, Bangkok, Thailand (Recruiting)
Study contacts
- Study coordinator: Thakrit Chompoosang, MD
- Email: tk_ortho@hotmail.com
- Phone: +66846461916
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.