Comparing pain relief methods for dental injections in children

Efficacy of Ethyl Chloride Topical Anesthesia Application on the Pain Perception During Intra-oral Injections in Children in Comparison to Benzocaine Gel- a Single-blinded Randomized Controlled Trial.

Not applicable Interventional Mohammed Bin Rashid University of Medicine and Health Sciences · NCT06011005

This study is testing whether a spray or a gel can help reduce pain for kids aged 7 to 10 during dental injections.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment42 (estimated)
Ages7 Years to 10 Years
SexAll
SponsorMohammed Bin Rashid University of Medicine and Health Sciences Academic / other
Locations1 site (Multiple Locations)
Trial IDNCT06011005 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to evaluate the effectiveness of Ethyl Chloride topical spray versus Benzocaine gel in reducing pain perception during dental injections in children aged 7 to 10 years. The study involves a single-blinded randomized controlled design where participants will receive either the Ethyl Chloride spray or Benzocaine gel before undergoing a maxillary buccal infiltration. Pain perception will be assessed using various scales, including the Visual Analog Scale and Facial Pain Scale, while monitoring heart rate as an additional measure of discomfort. The trial is conducted at the Pediatric Dentistry Department of Dubai Dental Hospital.

Who should consider this trial

Good fit: Ideal candidates for this study are healthy children aged 7 to 10 years who require maxillary buccal infiltration and have no prior history of local anesthesia.

Not a fit: Patients with a history of medically compromised conditions, allergies to local anesthesia, or those requiring treatment under conscious sedation may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved pain management techniques for children undergoing dental procedures.

How similar studies have performed: Previous studies have explored various topical anesthetics, but the specific comparison of Ethyl Chloride and Benzocaine in this context is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Healthy children (ASA I) aged between 7 - 10 years old.
* Needing any maxillary buccal infiltration (anterior, middle, posterior)
* Had no prior history of local anesthesia.
* Frankl behavior III or IV
* Not taking any painkillers, or other drugs that would influence with their pain perception.

Exclusion Criteria:

* History of a medically compromised condition and intellectual disability. § Any allergy to local anesthesia.
* Active pathology at the site of injection.
* Prior history of intra-oral injection.
* Frankl behavior I or II.
* Children/parents not willing to participate in the study. § Needle phobia.
* Patients require treatment under conscious sedation.

Where this trial is running

Multiple Locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Dental Caries in ChildrenAnesthesia, LocalInjection Site Discomfort
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.