Comparing pain relief methods after thumb surgery
Pain Relief After Trapeziectomy Without Opioids: Ibuprofen & Acetaminophen Versus Oxycodone
This study tests whether a mix of ibuprofen and acetaminophen can help people manage pain after thumb surgery better than oxycodone, with the goal of reducing the use of stronger painkillers.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 121 (estimated) |
| Ages | 45 Years and up |
| Sex | All |
| Sponsor | Stanford University Academic / other |
| Locations | 2 sites (Redwood City, California and 1 other locations) |
| Trial ID | NCT04676802 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of a combination of ibuprofen and acetaminophen versus oxycodone for managing postoperative pain following trapeziectomy for osteoarthritis at the base of the thumb. The aim is to reduce reliance on prescription opioids, which are known for their addictive potential, while still providing adequate pain control during the recovery phase. Participants will be monitored for pain relief over the first 30 days after surgery, assessing the efficacy of non-narcotic medications compared to traditional opioid treatment.
Who should consider this trial
Good fit: Ideal candidates are individuals undergoing trapeziectomy for thumb osteoarthritis who are proficient in English.
Not a fit: Patients who are currently using opioids or have certain medical conditions that contraindicate the use of the study medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to safer pain management strategies that minimize opioid use after surgery.
How similar studies have performed: Other studies have shown promise in reducing opioid use through non-narcotic pain management strategies, making this approach both relevant and timely.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Undergoing trapeziectomy for thumb osteoarthritis English proficient, Exclusion Criteria: * Pregnancy Current use of opioids Concurrent surgeries (ex. trapeziectomy combined with carpal tunnel release) Inability to complete study forms (education, cognitive ability, mental status, medical status) Allergy or intolerance to Ibuprofen, Acetaminophen and/or Oxycodone Liver or kidney dysfunction, abnormal liver enzymes restricting use of acetaminophen or ibuprofen History of chronic heart failure, upper gastrointestinal bleeding or coagulopathy History of complex regional pain syndrome
Where this trial is running
Redwood City, California and 1 other locations
- Stanford Health Care — Redwood City, California, United States (Recruiting)
- University of Utah Health Care — Salt Lake City, Utah, United States (Recruiting)
Study contacts
- Principal investigator: Amy Ladd, MD — Stanford Orthopaedic Surgery
- Study coordinator: Deborah Kenney, MS OTR
- Email: dkenney@stanford.edu
- Phone: 6507217644
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.