Comparing pain relief methods after esophageal surgery
Paravertebral Block With Liposomal Bupivacaine and Epidural Block With Plane Bupivacaine for Postoperative Analgesia in Esophageal Surgery: A Randomized, Non-inferiority Study
This study is testing whether a new pain relief method using liposomal bupivacaine works better than the standard epidural for patients recovering from esophageal surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 132 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Zhejiang Cancer Hospital Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT06704698 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of a transversus paravertebral block using liposomal bupivacaine versus traditional epidural analgesia for managing postoperative pain in patients undergoing thoracoscopic esophagectomy. A total of 132 patients will be enrolled, and their pain relief will be assessed using the Overall Benefit of Analgesic Score (OBAS). The study aims to determine if the newer liposomal bupivacaine provides superior pain control while minimizing opioid use and enhancing patient satisfaction. Participants will receive either the liposomal bupivacaine or standard bupivacaine treatment, with postoperative pain managed through patient-controlled analgesia.
Who should consider this trial
Good fit: Ideal candidates are patients with ASA physical status I-III scheduled for elective thoracoscopic esophagectomy.
Not a fit: Patients with contraindications for local nerve block, chronic pain, or those on anticoagulants or opioids may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved pain management and recovery for patients undergoing esophageal surgery.
How similar studies have performed: Other studies have shown promising results with ultrasound-guided regional nerve blocks, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologist physical status I-III; * Scheduled elective thoracoscopic esophagectomy(three-incision approach); * Approved participation before study. Exclusion Criteria: * Patients with contraindications for local nerve block such as spinal anatomic structure abnormality or local infection of puncture area; * Anergic to medications used in this study; * Patient have chronic pain; * Patient receiving anticoagulants, opioids or have a history of narcotic abuse or alcohol abuse; * Inability to complete postoperative pain assessments or questionnaires due to communication barriers or mental disorders;
Where this trial is running
Hangzhou, Zhejiang
- Jiangling Wang — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Principal investigator: Jiangling Wang, Ph.D — Zhejiang Cancer Hospital
- Study coordinator: Jiangling Wang, M.D
- Email: wangjl@zjcc.org.cn
- Phone: +8615168373331
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.