Clinical trial Recruiting at 1 site Interventional Ages 18 to 64

Comparing pain relief effects of upper and lower limb resistance training

Official title: Exercise-Induced Hypoalgesia Differences at Proximal and Distal Regions After Applying a Lower Limb Resistance Training or an Upper Limb Resistance Training Protocol: A Randomized Controlled Trial in Healthy Participants

Run by Centro Universitario La Salle · NCT06765486 · Data updated 2026-11-12

This study tests whether doing resistance exercises for the upper or lower body can help healthy people feel less pain after working out.

Quick facts

Study typeInterventional
Ages18 Years to 64 Years
SexAll
Enrollment90 (estimated)
SponsorCentro Universitario La Salle
Academic / other
Locations1 site (Madrid)
StatusRecruiting
StartedFebruary 15, 2025
Main results expectedMay 20, 2025
Study endsJune 1, 2025
Registry record updatedFebruary 26, 2025
Trial IDNCT06765486 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are healthy individuals aged 18 to 64 without any history of pain or significant medical conditions.

Probably not a fit

Patients with cardiovascular, respiratory, metabolic, neurological, or osteomuscular conditions, or those experiencing pain, will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial investigates the effects of resistance training on exercise-induced hypoalgesia in healthy individuals. Participants will be divided into three groups: one performing lower limb resistance exercises, another focusing on upper limb exercises, and a control group. The study will measure pressure pain thresholds in both the thigh and elbow to assess differences in pain relief between the trained regions. The goal is to determine how different resistance training interventions influence local and distal hypoalgesia.

Why it matters

Potential benefit: If successful, this study could provide insights into optimizing resistance training for pain management.

How similar studies have gone: While there is existing research on exercise-induced hypoalgesia, this specific comparison of upper and lower limb resistance training is a novel approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Asymptomatic subjects aged between 18 and 64 years.

Exclusion Criteria:

* Cardiovascular, respiratory, metabolic, neurological, or osteomuscular signs or pathologies.
* History of epilepsy.
* Pregnant.
* Participants who present any type of pain on the day of the measurements or who have frequently suffered pain during the previous 12 weeks.

Where it's running

  • CSEU LaSalle
    Madrid, Spain
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.