Comparing pain relief effects of upper and lower limb resistance training

Exercise-Induced Hypoalgesia Differences at Proximal and Distal Regions After Applying a Lower Limb Resistance Training or an Upper Limb Resistance Training Protocol: A Randomized Controlled Trial in Healthy Participants

Not applicable Interventional Centro Universitario La Salle · NCT06765486

This study tests whether doing resistance exercises for the upper or lower body can help healthy people feel less pain after working out.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment90 (estimated)
Ages18 Years to 64 Years
SexAll
SponsorCentro Universitario La Salle Academic / other
Locations1 site (Madrid)
Trial IDNCT06765486 on ClinicalTrials.gov

What this trial studies

This randomized controlled trial investigates the effects of resistance training on exercise-induced hypoalgesia in healthy individuals. Participants will be divided into three groups: one performing lower limb resistance exercises, another focusing on upper limb exercises, and a control group. The study will measure pressure pain thresholds in both the thigh and elbow to assess differences in pain relief between the trained regions. The goal is to determine how different resistance training interventions influence local and distal hypoalgesia.

Who should consider this trial

Good fit: Ideal candidates are healthy individuals aged 18 to 64 without any history of pain or significant medical conditions.

Not a fit: Patients with cardiovascular, respiratory, metabolic, neurological, or osteomuscular conditions, or those experiencing pain, will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide insights into optimizing resistance training for pain management.

How similar studies have performed: While there is existing research on exercise-induced hypoalgesia, this specific comparison of upper and lower limb resistance training is a novel approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Asymptomatic subjects aged between 18 and 64 years.

Exclusion Criteria:

* Cardiovascular, respiratory, metabolic, neurological, or osteomuscular signs or pathologies.
* History of epilepsy.
* Pregnant.
* Participants who present any type of pain on the day of the measurements or who have frequently suffered pain during the previous 12 weeks.

Where this trial is running

Madrid

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Local HypoalgesiaDistal HypoalgesiaResistance TrainingPressure Pain Thresholds
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.