Comparing pain management methods after knee surgery
The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral Total Knee Arthroplasty: a Randomized Controlled Trial
This study tests a new way to manage pain after knee surgery to see if it works better than the usual treatments like opioids and NSAIDs.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 50 Years to 85 Years |
| Sex | All |
| Sponsor | Damascus University Academic / other |
| Locations | 1 site (Damascus) |
| Trial ID | NCT06112548 on ClinicalTrials.gov |
What this trial studies
This interventional study aims to evaluate the effectiveness of a multimodal drug injection technique for pain management in patients undergoing primary unilateral total knee arthroplasty (TKA) compared to standard pain control methods that include opioids and NSAIDs. Patients will be randomly assigned to receive either the new injection method or the standard treatment, and their postoperative pain levels and functional outcomes will be assessed. The study will also monitor for any complications associated with the injection technique. Data collection will be conducted by blinded researchers to ensure objectivity.
Who should consider this trial
Good fit: Ideal candidates are individuals with end-stage arthritis of the knee who are scheduled for primary unilateral total knee arthroplasty.
Not a fit: Patients with inflammatory arthritis, a history of opioid addiction, or those with certain medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved pain management and reduced reliance on opioids for TKA patients.
How similar studies have performed: Previous studies have shown promising results with multimodal pain management approaches, suggesting potential for success in this trial.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * all patients with end-stage arthritis of the knee going primary unilateral total knee arthroplasty. Exclusion Criteria: * inflammatory and secondary arthritis of the knee. * Patients who are allergic to one or more of the drugs used in the injections. * Patients who are already taking opioids for whatever reason or have a history of addiction. * BMI less than 20 and more than 35. * patients with intra-operative complications that would affect the outcomes measurement. * Patients who are going through complex primary or revision TKA. * Pregnancy, renal or liver failure. * Patients who are classified as grade 3 or more according to ASA.
Where this trial is running
Damascus
- Damascus university — Damascus, Syrian Arab Republic (Recruiting)
Study contacts
- Study coordinator: jaber ibrahim, MD PHD
- Email: drjaberhibrahim@gmail.com
- Phone: 944411241
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.