Comparing pain levels in orthodontic treatments with clear aligners and fixed braces

Comparison of Self-reported and Experimental Pain Outcomes Between Clear Aligners and Fixed Appliances in Patients Undergoing Orthodontic Treatment

Observational Midwestern University · NCT06426238

This study is testing whether people using clear aligners or fixed braces feel more pain during their orthodontic treatment over five days after adjustments.

Quick facts

Study typeObservational
Enrollment38 (estimated)
Ages14 Years and up
SexAll
SponsorMidwestern University Academic / other
Locations1 site (Downers Grove, Illinois)
Trial IDNCT06426238 on ClinicalTrials.gov

What this trial studies

This observational study aims to evaluate and compare self-reported pain and experimental pain perception in patients undergoing orthodontic treatment with either clear aligners or fixed appliances. It will utilize Pressure Pain Threshold (PPT) as an objective measure to assess pain levels at various time points during the treatment phase. The study will focus on patients starting treatment at Midwestern University and will track pain perception over five days following appliance adjustments.

Who should consider this trial

Good fit: Ideal candidates are adolescents over 14 years old beginning orthodontic treatment with either clear aligners or fixed appliances.

Not a fit: Patients with systemic conditions affecting pain perception or untreated dental issues may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into pain management strategies for orthodontic patients.

How similar studies have performed: While studies have assessed pain levels in orthodontics, this approach using PPT for comparison between aligners and fixed braces is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* consecutive consented patients (\> 14 years old) beginning an orthodontic treatment on both arches, either with aligners or fixed appliance at the Midwestern University, Multidisciplinary Clinic;
* patients in possession of an email address and Internet connection.

Exclusion Criteria:

* patients with generalized systemic conditions known to affect the overall body pain and pressure pain threshold assessment (e.g., fibromyalgia, autoimmune conditions such as multiple sclerosis, rheumatoid arthritis),
* untreated dental caries.

Where this trial is running

Downers Grove, Illinois

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions PainPressure pain thresholdClear alignersOrthodontic applianceAdolescentsSelf-reported pain
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.