Comparing pain control methods after wisdom tooth removal
Comparative Effectiveness of Preemptive Ibuprofen, Ketamine, and Their Combination in Postoperative Pain and Trismus Management Following Third Molar Surgery
This study is testing whether ibuprofen, ketamine, or a combination of both can help people feel less pain and have less jaw stiffness after getting their wisdom teeth removed.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 25 Years |
| Sex | All |
| Sponsor | TC Erciyes University Academic / other |
| Locations | 1 site (Kayseri) |
| Trial ID | NCT05923775 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of ibuprofen, ketamine, and their combination in managing postoperative pain and trismus following third molar surgery. A total of 100 participants will be randomly assigned to four groups, with one group receiving ibuprofen, another receiving ketamine, and a third group receiving both treatments prior to surgery. The study will assess which method provides the best pain relief and reduces trismus after the extraction of impacted third molars. The trial is conducted at Erciyes University Faculty of Dentistry.
Who should consider this trial
Good fit: Ideal candidates are patients with a fully embedded third molar tooth in the mandible and a healthy general systemic condition.
Not a fit: Patients with fully erupted or partially embedded third molars, allergies to NSAIDs or anesthetics, or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing third molar surgery.
How similar studies have performed: Other studies have shown varying degrees of success with similar analgesic approaches, but this specific combination is being evaluated for the first time.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with a fully embedded third molar tooth in the mandible * Patients with regular attendance for routine follow up * Patients with a healthy general systemic condition Exclusion Criteria: * Patients with a fully erupted or partially embedded third molar tooth in the mandible * Patients who have previously experienced allergies to NSAIDs, local anesthetics, and ketamine * Pregnant or breastfeeding patients * Patients who have recently used a different group of NSAIDs for a different condition
Where this trial is running
Kayseri
- Erciyes University Faculty of Dentistry — Kayseri, Turkey (Recruiting)
Study contacts
- Study coordinator: Cihan Topan, Doctor
- Email: cihantopan@hotmail.com
- Phone: 05556456587
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.