Comparing oxytocin and prostaglandins for labor induction in women with an unfavorable cervix

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to determine the most effective management strategy for women with an unfavorable cervix after 24 hours of cervical ripening. It compares the use of oxytocin for labor induction against repeated cervical ripening with prostaglandins. The study focuses on minimizing maternal and perinatal morbidity while maximizing maternal satisfaction. Participants will be monitored to assess outcomes related to cesarean delivery rates and overall labor progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pregnant woman
* ≥ 18 years old
* With a singleton cephalic pregnancy
* ≥37+0 weeks of gestation
* Gestational age estimated from the first trimester ultrasound (realized between 11+0 and 13+6 weeks of gestation)
* With a medical indication of labor with a previous pharmacological or mechanical cervical ripening of 24 hours
* Bishop score ≤ 6 at inclusion (unfavorable cervix)
* French health insurance policy holder
* Written informed consent

Exclusion Criteria:

* Any measures of legal protection
* Prior caesarean section or uterine scar
* Contra-indications to a vaginal delivery
* Foetus with suspected severe congenital abnormalities
* Pathological foetal heart rate
* Contra-indications to ANGUSTA® (oral misoprostol, cervical ripening agent)
* Contra-indications to PROPESS® (vaginal slow releasing system of dinoprostone, cervical ripening agent)
* Contra-indications to PROSTINE® (vaginal gel of dinoprostone, cervical ripening agent)
* Contra-indications for using oxytocin
* Woman in labor

Where it's running

• Gynaecology-obstetrics, University Hospital, Angers
  Angers, France Recruiting
• Gynaecology-obstetrics, University Hospital, Brest
  Brest, France Recruiting
• Gynaecology-obstetrics, University Hospital, Nancy
  Nancy, France Recruiting
• Gynaecology-obstetrics, University Hospital, Nantes
  Nantes, France Recruiting
• Gynaecology-obstetrics, University Hospital, Orléans
  Orléans, France Recruiting
• Gynaecology-obstetrics, Port Royal Maternity Hospital, Paris
  Paris, France Recruiting

Study contacts

• Study coordinator: Caroline DIGUISTO, MD
• Email: carolinediguisto@gmail.com
• Phone: 02 47 47 47 39

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• PGE2 then oxytocin versus oxytocin for starting labor after your water breaks at term.

  This test will see whether giving a 6-hour vaginal dinoprostone (PGE2) insert before oxytocin or starting oxytocin right away works better for women 18 and older with a single baby whose water breaks at 37–42 weeks and whose cervix isn't ready.

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• Serial membrane sweeping to encourage spontaneous labor at term

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• Evaluating membrane stripping for cervical ripening in labor induction

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  Recruiting Meir Medical Center · Kfar Saba, Central District · NCT06591247

• Cervical ripening balloon left in place for 3 hours vs 12 hours during labor induction

  This study tests whether keeping the cervical ripening balloon in for 3 hours works as well as the standard 12 hours to shorten time to delivery in pregnant people induced for labor.

  Recruiting Rambam Health Care Campus · Haifa · NCT07689357

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.