Comparing oxygen flow rates during preoxygenation with high-flow nasal oxygen
Comparison of Different Oxygen Flow Rates During Preoxygenation Using High-Flow Nasal Oxygen
This study tests if using different oxygen flow rates with high-flow nasal oxygen can help patients breathe better before surgery compared to regular oxygen methods.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 75 (estimated) |
| Ages | 18 Years to 84 Years |
| Sex | All |
| Sponsor | Region Stockholm Government |
| Locations | 1 site (Solna) |
| Trial ID | NCT06736132 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of different oxygen flow rates using high-flow nasal oxygen (HFNO) during the preoxygenation phase before anesthesia induction. HFNO is known for its ability to maintain oxygen levels even during apnoea, making it particularly useful in surgeries involving the airway. The study aims to compare HFNO's efficacy against traditional oxygen delivery methods, focusing on patient comfort and ease of use for anesthetists. By assessing the impact of varying flow rates, the research seeks to optimize preoxygenation strategies for elective surgeries.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18-84, classified as ASA 1-3, with a BMI under 35, and scheduled for elective surgery.
Not a fit: Patients with significant cardiac or respiratory conditions, those who are pregnant, or individuals with known difficult airways may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance patient safety and comfort during anesthesia induction by optimizing oxygen delivery methods.
How similar studies have performed: Previous studies have shown promising results with high-flow nasal oxygen in similar contexts, indicating a potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult, 18-84 years old * ASA 1-3 * BMI \< 35 * Planned for elective surgery Exclusion Criteria: * Cardiac disease (ischemic heart disease, heart failure (NYHA ≥2), ongoing arrhythmias, pulmonary hypertension) * Severe asthma, moderate to severe COPD * Pregnancy * Smokers or former smoker last finished 1 year before inclusion * Baseline oxygen saturation \< 95% * Nasal obstruction * Known or anticipated difficult airway * Patients with electrical active implants where lung impedance analysis is contraindicated * Not capable of understanding study information and signing a written consent
Where this trial is running
Solna
- Karolinska University Hospital — Solna, Sweden (Recruiting)
Study contacts
- Study coordinator: Albin Sjöblom, MD, PhD
- Email: albin.sjoblom@ki.se
- Phone: +46704154346
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.