Comparing oral and vaginal misoprostol for inducing labor
Comparison of Oral Versus Vaginal Misoprostol for Labour Induction at Term
This study is testing whether using vaginal misoprostol to induce labor is more effective than taking it by mouth for women who are ready to give birth.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Enrollment | 176 (estimated) |
| Ages | 20 Years to 40 Years |
| Sex | Female |
| Sponsor | Services Institute of Medical Sciences, Pakistan Government |
| Locations | 1 site (Lahore, Punjab) |
| Trial ID | NCT05957666 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to compare the effectiveness of oral versus vaginal misoprostol for inducing labor in women at term with a Bishop score of 6 or less. It is a randomized control trial involving 176 patients who will receive either oral or vaginal misoprostol in a standardized dosage. The study will monitor uterine contractions and fetal heart rates, assessing labor progress through regular examinations and partograms. The goal is to determine if the vaginal route leads to a lower cesarean section rate compared to the oral route.
Who should consider this trial
Good fit: Ideal candidates for this study are pregnant women at term with a Bishop score of 6 or less who require labor induction.
Not a fit: Patients with previous uterine scars, multiple gestations, or severe systemic illnesses may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a more effective method for labor induction, potentially reducing cesarean section rates.
How similar studies have performed: Other studies have shown varying success with misoprostol for labor induction, but this specific comparison of oral versus vaginal administration is less commonly tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Cephalic presentation Prelabour rupture of membranes Singleton pregnancies reaching 41 weeks G1 to G4 Bishop score of less than or equal to 6 Medical disorders(GDM,PIH) - Exclusion Criteria: Previous uterine scar Antepartum hemorrhage Cephalopelvic disproportion Multiple gestation Multiparity Oligohydramnios/polyhydramnios IUGR Severe systemic illness like pre eclampsia,eclampsia,cardiac,hepatic,renal disease PPROM -
Where this trial is running
Lahore, Punjab
- Services Institute Of Medical Sciences — Lahore, Punjab, Pakistan (Recruiting)
Study contacts
- Study coordinator: Tayyiba Wasim, FCPS
- Email: tayyibawasim@yahoo.com
- Phone: 03008400197
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.