Comparing oral and IV fluids after knee surgery

Comparison Efficacy of Oral Fluid Versus Intravenous Fluid Replacement in Postoperative Primary Total Knee Arthroplasty : A Randomized Controlled Trial.

Not applicable Interventional Thammasat University Hospital · NCT06288815

This study is testing whether drinking fluids or getting them through an IV helps people recover faster after knee surgery.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment130 (estimated)
Ages40 Years to 85 Years
SexAll
SponsorThammasat University Hospital Academic / other
Locations1 site (Khlong Luang, Pathum Thani)
Trial IDNCT06288815 on ClinicalTrials.gov

What this trial studies

This study aims to compare the effectiveness of oral fluid replacement versus intravenous fluid replacement in patients recovering from primary unilateral total knee arthroplasty. It will assess whether patients who receive oral fluids recover faster than those who receive IV fluids. The study will include patients aged 40 to 85 years with primary osteoarthritis and will exclude those with certain medical conditions or previous knee surgeries. The goal is to determine the optimal fluid replacement method to enhance recovery post-surgery.

Who should consider this trial

Good fit: Ideal candidates are individuals aged 40-85 with primary osteoarthritis who are classified as ASA I or II.

Not a fit: Patients who are on diuretics, are morbidly obese, have had previous knee surgeries, or cannot undergo spinal anesthesia may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved recovery times for patients undergoing knee surgery.

How similar studies have performed: While there may be limited data on this specific comparison, similar studies have explored fluid replacement methods in surgical recovery with varying results.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 40-85 years old
* ASA I, II
* Primary osteoarthritis

Exclusion Criteria:

* Diuretics use
* Morbid obesity
* Previous knee surgery
* Cannot undergo spinal anesthesia

Where this trial is running

Khlong Luang, Pathum Thani

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Osteoarthritis, KneeTotal Knee ArthroplastyOral Fluid Replacement
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.