Comparing oral and intratympanic corticosteroids for sudden hearing loss

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to determine the effectiveness of two corticosteroid treatment methods for patients with sudden sensorineural hearing loss: oral methylprednisolone and intratympanic dexamethasone. Participants will be divided into two groups, with one receiving oral medication and the other receiving intratympanic injections over a specified treatment period. Follow-up visits will occur at regular intervals to assess hearing recovery and overall outcomes. The study seeks to provide clarity on which treatment option yields better results for patients experiencing this condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years of age and older
* Unilateral sudden sensorineural hearing loss that developed within 72 hours and has lasted for 14 days or less
* Affected side PTA (500-100-2000-4000hz) should be over 50dB
* Affected side should be at least 30dB lower than healthy side in 3 frequencies
* Hearing should be symmetrical according to patient's statement before sensorineural hearing loss
* If used, steroid use should be less than 10 days
* Cerebellar and vestibular examination should be normal

Exclusion Criteria:

* Having a history of hearing-related surgery other than a ventilation tube
* Having a history of previous hearing loss, fluctuating hearing or Meniere's disease, chronic inflammatory or suppurative ear disease or cholesteatoma, otosclerosis
* Being under 18 or over 80
* Having a history of physical-barotrauma
* Presence of structural or retrocochlear pathology in the examination and imaging that would explain the unilateral hearing loss
* Patients diagnosed with tuberculosis or receiving prophylactic tuberculosis treatment, diabetes mellitus, rheumatological patients, those with atherosclerotic disease, serious psychiatric patients, those receiving chemotherapy, radiotherapy or immunosuppressant treatment, pancreatitis patients, HIV, hepatitis C and B patients, those with chronic renal failure, substance abusers, those with active herpetic lesions, severe osteoporosis patients, those with hearing loss within 4 weeks after general anesthesia, those with a history of head and neck cancer.

Where it's running

• Dr Lütfi Kırdar City Hospital
  Istanbul, Kartal, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Koray Islek
• Email: islekkoray@gmail.com
• Phone: +905380457016

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.