Comparing oral and injectable dexamethasone for treating mild to moderate croup in children
Efficacy Of Oral Dexamethasone Versus Parenteral Dexamethasone In The Management Of Mild To Moderate Croup
This study is testing whether giving dexamethasone by mouth works as well as giving it by injection for treating mild to moderate croup in children aged 2 to 12.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 192 (estimated) |
| Ages | 2 Years to 12 Years |
| Sex | All |
| Sponsor | Khyber Teaching Hospital Academic / other |
| Locations | 1 site (Peshawar, KPK) |
| Trial ID | NCT06959407 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of oral dexamethasone compared to intramuscular dexamethasone in managing mild to moderate croup, a common viral infection in children. It focuses on children aged 2 to 12 years who have been diagnosed with croup. The research aims to fill the gap in existing data regarding treatment efficacy in non-hospitalized patients, as most previous studies have concentrated on hospitalized cases. By comparing these two administration routes, the study seeks to provide better guidance for treatment options in outpatient settings.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 2 to 12 years diagnosed with mild to moderate croup.
Not a fit: Patients with chronic pulmonary diseases, allergies to corticosteroids, or those who have received corticosteroids recently may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment protocols for children with croup, potentially reducing the need for hospital visits.
How similar studies have performed: While there is limited data on outpatient treatment for mild croup, previous studies have shown varying effectiveness of dexamethasone in hospitalized patients, indicating a need for this novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient age 2 to 12 years * Both genders * Diagnosed with croup as operational definitions Exclusion Criteria: * Patients with chronic pulmonary disease like tuberculosis, * Allergy or contraindication of corticosteroid (history of tuberous sclerosis, history of varicella infection during the past three weeks), to corticosteroids, * history of corticosteroid administration during the last four weeks, * foreign body * patients with immunodeficiency disorder
Where this trial is running
Peshawar, KPK
- Khyber Teaching Hospital — Peshawar, Kpk, Pakistan (Recruiting)
Study contacts
- Study coordinator: Sadiq Akbar, MBBS
- Email: sadiqakbar77@yahoo.com
- Phone: +92 344 9888158
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.