Comparing one versus three hyperbaric oxygen treatments for carbon monoxide poisoning
Optimizing Hyperbaric Oxygen Treatments for Acute Carbon Monoxide Poisoning: An Open-label Randomized Study.
This study is testing if one session of hyperbaric oxygen therapy works just as well as three sessions for treating people with carbon monoxide poisoning.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 17 Years and up |
| Sex | All |
| Sponsor | University of Alberta Academic / other |
| Locations | 1 site (Edmonton, Alberta) |
| Trial ID | NCT06619717 on ClinicalTrials.gov |
What this trial studies
This study aims to determine whether a single session of hyperbaric oxygen therapy (HBO) is as effective as three sessions for treating patients with acute carbon monoxide poisoning. Patients will be randomly assigned to receive either one or three treatments, and their neurological outcomes will be measured to assess the effectiveness of each approach. Given the logistical challenges and costs associated with HBO treatment, understanding the optimal number of sessions is crucial for improving patient care. The study is conducted at the University of Alberta, which serves a wide geographic area in Canada.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 17 years old who have been referred to a hyperbaric unit for acute carbon monoxide poisoning.
Not a fit: Patients who are obtunded, mechanically ventilated, pregnant, incarcerated, or cognitively impaired will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could optimize treatment protocols for carbon monoxide poisoning, potentially improving patient outcomes and resource utilization.
How similar studies have performed: Previous studies have shown conflicting results regarding the number of hyperbaric treatments needed, making this a critical area for further investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All adult (over 17 years old) patients referred to a Hyperbaric Unit for acute carbon monoxide poisoning. Exclusion Criteria: * Obtunded * Mechanically ventilated * Pregnant * Incarcerated * Cognitively impaired (acutely or chronically)
Where this trial is running
Edmonton, Alberta
- University of Alberta — Edmonton, Alberta, Canada (Recruiting)
Study contacts
- Study coordinator: Jesse Hill
- Email: jlh1@ualberta.ca
- Phone: 780-735-2627
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.