Comparing Oliceridine with Morphine and Sufentanil for Pain Relief After Back Surgery
Comparison of the Analgesic Effect of Oliceridine Versus Morphine or Sufentanil for Postoperative Analgesia in Lumbar Surgeries: a Randomized Control Trial
This study is testing whether a new pain medication called Oliceridine works better than Morphine and Sufentanil for relieving pain after back surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Anqing Municipal Hospital Academic / other |
| Locations | 1 site (Anqing, Anhui) |
| Trial ID | NCT06990893 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness and safety of Oliceridine compared to Morphine and Sufentanil for managing postoperative pain in patients undergoing orthopedic lumbar spine surgery. Ninety patients aged 18 to 65 with ASA physical status I to III will be randomly assigned to one of three groups, receiving either Oliceridine, Morphine, or Sufentanil. Each group will receive a specific loading dose followed by a continuous infusion of the assigned analgesic. The study will assess pain relief outcomes and any associated side effects.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 scheduled for lumbar spine surgery with ASA grades I to III.
Not a fit: Patients with severe respiratory or circulatory diseases, nervous system disorders, or those with abnormal liver and kidney functions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a more effective and safer pain management option for patients after lumbar surgery.
How similar studies have performed: Other studies have shown promising results with Oliceridine, suggesting it may be a viable alternative to traditional opioids, although this specific comparison is less common.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Lumbar spine surgery with ASA grades I-III * Aged 18-65 years * Ethically, the patient voluntarily accepted this trial and signed the informed consent form Exclusion Criteria: * Severe respiratory and circulatory system diseases * Nervous system disease * Mental and psychological disorders * Abnormal liver and kidney functions * Participated in another drug clinical research within the past 30 days
Where this trial is running
Anqing, Anhui
- Department of Anqing Hospital Anesthesiology — Anqing, Anhui, China (Recruiting)
Study contacts
- Study coordinator: Sun Ling Lu Sun Ling LU, Master's degree
- Email: 348092640@qq.com
- Phone: 15955565806
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.