Comparing Oliceridine with Morphine and Sufentanil for Pain Relief After Back Surgery
Official title: Comparison of the Analgesic Effect of Oliceridine Versus Morphine or Sufentanil for Postoperative Analgesia in Lumbar Surgeries: a Randomized Control Trial
Run by Anqing Municipal Hospital · NCT06990893 · Data updated 2026-11-12
This study is testing whether a new pain medication called Oliceridine works better than Morphine and Sufentanil for relieving pain after back surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | Anqing Municipal Hospital Academic / other |
| Locations | 1 site (Anqing, Anhui) |
| Status | Recruiting |
| Started | June 1, 2025 |
| Main results expected | October 1, 2026 |
| Study ends | October 1, 2026 |
| Registry record updated | June 1, 2026 |
| Trial ID | NCT06990893 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 65 scheduled for lumbar spine surgery with ASA grades I to III.
✕Probably not a fit
Patients with severe respiratory or circulatory diseases, nervous system disorders, or those with abnormal liver and kidney functions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the effectiveness and safety of Oliceridine compared to Morphine and Sufentanil for managing postoperative pain in patients undergoing orthopedic lumbar spine surgery. Ninety patients aged 18 to 65 with ASA physical status I to III will be randomly assigned to one of three groups, receiving either Oliceridine, Morphine, or Sufentanil. Each group will receive a specific loading dose followed by a continuous infusion of the assigned analgesic. The study will assess pain relief outcomes and any associated side effects.
Why it matters
Potential benefit: If successful, this study could provide a more effective and safer pain management option for patients after lumbar surgery.
How similar studies have gone: Other studies have shown promising results with Oliceridine, suggesting it may be a viable alternative to traditional opioids, although this specific comparison is less common.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Lumbar spine surgery with ASA grades I-III * Aged 18-65 years * Ethically, the patient voluntarily accepted this trial and signed the informed consent form Exclusion Criteria: * Severe respiratory and circulatory system diseases * Nervous system disease * Mental and psychological disorders * Abnormal liver and kidney functions * Participated in another drug clinical research within the past 30 days
Where it's running
-
Department of Anqing Hospital Anesthesiology
Anqing, Anhui, China Recruiting
Study contacts
- Study coordinator: Sun Ling Lu Sun Ling LU, Master's degree
- Email: 348092640@qq.com
- Phone: 15955565806
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Using renal artery duplex ultrasound to check kidney blood flow in ICU patients with acute kidney injury
We will test whether a bedside renal artery duplex ultrasound measurement (renal resistive index) can detect early changes in kidney blood flow in critically ill adults with acute kidney injury.
-
Optimal spinal morphine dose for pain after cesarean delivery
This will test different doses of morphine given into the spinal fluid to find the best dose for reducing pain after an elective cesarean in adult women.
-
Comparing different tracheal catheters for women undergoing thyroid surgery
This study is testing which size of tracheal catheter causes the least sore throat after thyroid surgery in women.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.