Comparing normal saline and Ringer's solution for heat stroke treatment
The Relationship Between Normal Saline Infusion and Acute Kidney Injury in Patients With Heat Stroke
This study tests whether using less normal saline with Ringer's solution can help prevent kidney problems and improve survival in people with heat stroke.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 190 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University Academic / other |
| Locations | 7 sites (Guli, Zhejiang and 6 other locations) |
| Trial ID | NCT05921695 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effects of normal saline infusion versus sodium lactate Ringer's solution on renal function in patients diagnosed with heat stroke. Participants will receive either a standard normal saline infusion or a restricted normal saline infusion while receiving Ringer's solution in the emergency department. The primary objective is to determine if limiting normal saline can reduce the incidence of acute kidney injury and mortality in these patients. The study will compare outcomes between the two groups to assess the effectiveness of the interventions.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who have been diagnosed with heat stroke.
Not a fit: Patients requiring immediate cardiopulmonary resuscitation, those with end-stage renal disease, or severe organ damage will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment protocols for heat stroke, potentially reducing kidney injury and mortality rates.
How similar studies have performed: While there is limited data on this specific comparison, similar studies have explored fluid management in heat stroke, indicating potential for impactful findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ≥ 18 years * diagnosed as heat stroke * Informed consent from patients or family members. Exclusion Criteria: * need immediate cardiopulmonary resuscitation * transferred from another hospital * with original end-stage renal disease or dialysis * with severe organ damage * pregnant women
Where this trial is running
Guli, Zhejiang and 6 other locations
- YongKang First People's Hospital — Guli, Zhejiang, China (Recruiting)
- Yiwu Central Hospital — Yiwu, Zhejiang, China (Recruiting)
- Dongyang People's Hospital — Dongyang, China (Recruiting)
- The Second Affiliated Hospital of Zhejiang University School of Medicine — Hangzhou, China (Recruiting)
- Jinhua Municipal Central Hospital — Jinhua, China (Recruiting)
- Jinhua People's Hospital — Jinhua, China (Recruiting)
- Lanxi People's Hospital — Lanxi, China (Recruiting)
Study contacts
- Principal investigator: Lan Chen, PHD — Second Affiliated Hospital, School of Medicine, Zhejiang University
- Study coordinator: Xiuqin Feng, PRO
- Email: fengxiuqin@zju.edu.cn
- Phone: 8613757119151
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.