Comparing norepinephrine and phenylephrine to prevent low blood pressure during spinal anesthesia in emergency cesarean sections

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to determine whether norepinephrine is more effective than phenylephrine in preventing spinal anesthesia induced hypotension in obstetrical patients undergoing emergency cesarean sections. Participants will receive prophylactic boluses of both medications immediately after spinal anesthesia induction, and their hemodynamic parameters and neonatal APGAR scores will be monitored. The study is conducted at the K.M. Pfau Civil Hospital in Karachi, Pakistan, with data collected following ethical approval and informed consent. Randomization of participants will be performed using a lottery method to ensure unbiased results.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. American society of anesthesiologists II and III patients
2. Age 18-40years
3. Gestational age 32 weeks and above

Exclusion Criteria:

1. Patients with hypertensive disorders of pregnancy having baseline systolic blood pressure greater than 160 mmHg and diastolic blood pressure greater than 99 mmHg.
2. Baseline mean arterial pressure less than 70 mmHg.
3. Antepartum hemorrhage/intraoperative blood loss greater than 1000ml
4. history indicative of cardiovascular or neurological disease.
5. known fetal abnormality.
6. Patients taking serotonin reuptake inhibitor, Tricyclic antidepressants,monoamine oxidase inhibitors.
7. Maternal situations requiring immediate administration of general anesthesia

Where it's running

• Dr Ruth km pfau civil hospital karachi Dow University of health sciences, department of anesthesiology
  Karachi, Sindh, Pakistan Recruiting

Study contacts

• Study coordinator: Rabia Kamal, MBBS
• Email: rabiakamal.ae@gmail.com
• Phone: 923342239607

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Height-based versus conventional spinal anesthetic dosing for older adults having lower-limb surgery

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  Recruiting Shaheed Mohtarma Benazir Bhutto Institue of Trauma · Karachi, Sindh · NCT07363941

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.