Comparing non-invasive FFR‑CT with invasive FFR in a multi-ethnic hospital population
Correlation of Fractional Flow Reserve Computed Tomography (FFR CT) Findings With Invasive FFR in Coronary Artery Disease (CAD) in a Multi-ethnic Cohort- a Retrospective Study
This project will test whether non-invasive FFR‑CT measurements match invasive FFR in adults with suspected coronary artery disease who had both tests.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Sandwell & West Birmingham Hospitals NHS Trust Academic / other |
| Locations | 1 site (Birmingham, West Midlands) |
| Trial ID | NCT06790836 on ClinicalTrials.gov |
What this trial studies
This is a retrospective analysis of CT coronary angiography (CTCA) records from Sandwell and West Birmingham NHS Trust between January 2019 and December 2023, focusing on roughly 500 adults with stable chest pain who underwent CTCA, FFR‑CT, and invasive FFR. The clinical team will screen the database for eligible patients with high-quality CT images and extract paired FFR‑CT and invasive FFR results for comparison. Statistical correlation and diagnostic performance (sensitivity, specificity, predictive values) will be calculated overall and across ethnic groups to assess real-world accuracy. The goal is to clarify variability seen in prior observational work and inform whether FFR‑CT can reliably reduce invasive testing in routine practice.
Who should consider this trial
Good fit: Ideal candidates for inclusion are adults (≥18 years) with stable chest pain treated at SWBH NHS Trust between 2019 and 2023 who had high-quality CTCA, FFR‑CT, and invasive FFR performed.
Not a fit: Patients who did not have all three tests, who have poor-quality or artifact-laden CT images, acute coronary syndromes, or who were not treated at the Trust during the specified period are unlikely to benefit from the study's findings.
Why it matters
Potential benefit: If results show good agreement, validated FFR‑CT could reduce the need for invasive testing, lowering procedure-related risk and healthcare costs for patients.
How similar studies have performed: Prior randomized and observational studies showed promising sensitivity and specificity for FFR‑CT but real-world observational series have reported variable predictive values, with some large cohorts showing a low positive predictive value.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * •≥18 years * Stable •patients with suspected CAD * Patients who underwent CTCA, FFR CT and had an invasive FFR. * CTCA images of high-quality for analysis, with clear visualisation of coronary arteries and minimal artifacts. Exclusion Criteria: * •\<18 years of age * Did not undergo FFR CT * Inadequate quality/degraded CTCA images
Where this trial is running
Birmingham, West Midlands
- Sandwell and West Birmingham NHS Trust — Birmingham, West Midlands, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Vinoda Sharma, FRCP FESC FRCPE
- Email: vinodasharma@nhs.net
- Phone: 0044 1215075841
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.