Comparing new bone graft materials for preserving jawbone after tooth extraction
Mix of Demineralized Freeze-Dried Bone Allograft and Deproteinized Bovine Bone Mineral: a Possible Solution for Alveolar Ridge Preservation?
This study is testing a new bone graft material to see if it can better preserve jawbone after tooth extractions compared to a standard option, helping people who need implants in the future.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Nova Southeastern University Academic / other |
| Locations | 1 site (Fort Lauderdale, Florida) |
| Trial ID | NCT06275789 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of a new grafting material that combines demineralized freeze-dried bone allograft (DFDBA) and deproteinized bovine bone mineral (DBBM) for alveolar ridge preservation compared to a commonly used mineralized allograft. The research will assess both the dimensional changes and histological outcomes following flapless alveolar ridge preservation in patients requiring tooth extractions for future implant placement. By analyzing these factors, the study seeks to determine if the new combination material can better maintain bone volume and quality. The results will be crucial for planning successful implant-supported prostheses.
Who should consider this trial
Good fit: Ideal candidates are healthy individuals requiring the extraction of premolars or molars with plans for future dental implants.
Not a fit: Patients with uncontrolled systemic health issues, active periodontal disease, or those who smoke heavily may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved outcomes in dental implant procedures by better preserving jawbone structure after tooth extractions.
How similar studies have performed: Previous studies have shown that various grafting materials can effectively minimize dimensional changes, but this specific combination approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients in good health * Require the extraction of at least one premolar or molar with future implant placement * Sufficient keratinized gingiva (equal or more than 2mm prior to extraction), * No more than 3mm of buccal bone loss * Flapless extraction possible * Full mouth plaque index of less than 25% Exclusion Criteria: * Nicotine consumption equivalent to or more than 10 cigarettes per day * Electronic cigarette usage * A history of irradiation of head and neck area * Immunodeficiency disease * Uncontrolled systemic health problems (hypertension crisis 180/120, hyperthyroidism, diabetes with HbA1c over 7, recent history of stroke, cancer) History of medications that affect bone remodeling process (bisphosphonates, RANK-L inhibitors) * Previous adverse reaction to the biomaterials used * Pregnancy/lactation, or those who are trying to become pregnant. * Active uncontrolled or untreated periodontal disease * Periapical lesions greater than 1 cm and soft tissue pathology
Where this trial is running
Fort Lauderdale, Florida
- Nova Southeastern University — Fort Lauderdale, Florida, United States (Recruiting)
Study contacts
- Study coordinator: Andee Goldstein, DMD
- Email: ag3577@mynsu.nova.edu
- Phone: 7542599445
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.