Comparing new and traditional classifications of radiation oropharyngeal mucositis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to address the inconsistencies in the traditional grading system for radiation oropharyngeal mucositis, a painful side effect of radiotherapy in head and neck cancer patients. Researchers will classify mucositis into four types based on histopathological changes and compare the assessment consistency among different physicians using both new and traditional classifications. Additionally, the study will explore changes in blood markers associated with the different types of mucositis using clinical residual blood samples. The multicenter approach involves several hospitals in Guangdong, China.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Voluntarily sign informed consent;
* Age 18 or older on the date of signing the informed consent;
* Histologically confirmed head and neck tumor, radiotherapy or chemoradiotherapy.

Exclusion Criteria:

* They also have other uncontrolled serious medical conditions, such as unstable heart disease requiring treatment, poorly controlled diabetes (fasting blood glucose \> 1.5× the upper limit of normal), mental illness, and a history of severe allergies

Where it's running

• Southern medical university
  Guangzhou, Guangdong, China Recruiting
• Huizhou Central People's Hospital
  Huizhou, Guangdong, China Not yet recruiting
• Jieyang people's hospital
  Jieyang, Guangdong, China Not yet recruiting
• Meizhou People's Hospital, Meizhou Academy of Medical Sciences Meizhou
  Meizhou, Guangdong, China Not yet recruiting

Study contacts

• Principal investigator: Jian Guan, M.D — Nanfang Hospital, Southern Medical University
• Study coordinator: Jian Guan, M.D
• Email: guanjian5461@163.com
• Phone: +86-13632102247

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.