Comparing neuromuscular training and resistance training for knee pain relief

Effects of Neuromuscular Training Compared to Progressive Resistance Training on Patients With Anterior Knee Pain. A Randomized Controlled Trial

Not applicable Interventional University of Thessaly · NCT06110455

This study is testing whether a special exercise program for muscle control works better than a strength training program to help people with knee pain feel better.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment50 (estimated)
Ages18 Years to 40 Years
SexFemale
SponsorUniversity of Thessaly Academic / other
Locations1 site (Lamia, Central Greece)
Trial IDNCT06110455 on ClinicalTrials.gov

What this trial studies

This randomized control trial aims to compare the effectiveness of a neuromuscular training program (NMT) against a progressive resistance training program (PRT) for patients suffering from anterior knee pain. Participants will be divided into two groups, with each group undergoing an 8-week intervention consisting of supervised exercise sessions. Pain and functionality will be assessed using various scales and functional tests before and after the intervention. The study will also evaluate muscle strength, balance, kinesiophobia, and dynamic knee valgus as secondary outcomes.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals aged 18-40 who have experienced anterior knee pain for at least three months and meet specific pain and functional criteria.

Not a fit: Patients with significant knee injuries, such as patellar dislocation or ligament instability, or those with certain medical conditions like rheumatoid arthritis or metabolic diseases may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a more effective rehabilitation approach for patients with anterior knee pain, improving their pain levels and functional capabilities.

How similar studies have performed: While similar approaches have been explored, this specific comparison of neuromuscular training versus progressive resistance training for anterior knee pain is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Pain ≥ 3 months
* Pain VAS now ≥ 3
* 18-40 y/o
* No pain relief medicine 2 weeks prior to the program
* Kujala 50-80
* Pain during squat, knee bending, palpation, isometric contraction on 60°, long sitting, jumping, step up/down, running.
* Theatre sign
* Positive functional tests: grind test, 45 sec anterior knee provocation, McConnel

Exclusion Criteria:

* Patellar dislocation
* Lower extremity surgery
* Ligament instability
* Rheumatoid Arthritis
* Osteoarthritis
* Tendinopathy
* Meniscus tear
* Ligamentous knee injury or laxity
* Bursitis
* Sinding Larsen Johansson Syndrome
* Previous pathology
* Low back surgery
* Metabolic diseases
* NSAIDs for extended period of time
* Cardiorespiratory diseases
* Sacroiliac joint pain
* Pregnancy
* Physical therapy 2 months ago

Where this trial is running

Lamia, Central Greece

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Anterior Knee Pain Syndrome
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.