Comparing neuromuscular monitoring methods during anesthesia reversal
Comparison of the Performances of the Train-of-Four Ratio and the Modified Train-of-Four Ratio During Reversal of Deep Neuromuscular Blockade With Sugammadex
This study is testing two different ways to monitor muscle recovery during anesthesia to see which one helps prevent complications after surgery for adults aged 18 to 65.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 199 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Ankara University Academic / other |
| Locations | 1 site (Ankara, Altındağ) |
| Trial ID | NCT06220136 on ClinicalTrials.gov |
What this trial studies
This observational study evaluates the performance of two neuromuscular monitoring techniques, the classical train-of-four ratio (cTOFR) and the modified train-of-four ratio (mTOFR), during the reversal of deep neuromuscular blockade using Sugammadex. The study aims to address the high incidence of postoperative residual neuromuscular block, which can lead to serious complications. By utilizing TOFscan, a 3-dimensional acceleromyograph, the researchers will assess the effectiveness of these monitoring methods in ensuring patient safety and improving outcomes. The study includes patients aged 18 to 65 with a normal BMI and excludes those with certain medical conditions or complications.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 65 with a BMI between 18.5 and 24.9 undergoing elective surgeries requiring neuromuscular blockade.
Not a fit: Patients with liver or kidney disease, muscle disorders, or those undergoing emergency surgeries may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance patient safety by reducing the incidence of postoperative residual neuromuscular block.
How similar studies have performed: Previous studies have shown promising results with similar neuromuscular monitoring approaches, indicating potential for success in this study.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 18 - 65 (not including 65) * BMI: 18.5-24.9 Exclusion Criteria: * Liver and kidney disease * Non-consenting * Emergency surgeries * Muscle disease * Allergy to rocuronium and sugammadex * Patients predicted to have difficult mask ventilation or difficult intubation * Pregnant and breastfeeding women
Where this trial is running
Ankara, Altındağ
- Ankara University — Ankara, Altındağ, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Hatice Güneş Yeşilova, 2 — Ankara University
- Study coordinator: Hatice Güneş Yeşilova, 1
- Email: htcguness@hotmail.com
- Phone: +905510495354
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.