Comparing nebulized amphotericin B and saline for chronic pulmonary aspergillosis treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial aims to evaluate the effectiveness of nebulized amphotericin B compared to nebulized normal saline as a maintenance therapy for patients with chronic pulmonary aspergillosis (CPA) who have previously been treated with oral itraconazole. The study will involve patients who have completed 12 months of itraconazole therapy, assessing the safety and efficacy of the nebulized treatment approach. Given the significant burden of CPA and the limitations of current therapies, this trial seeks to provide a potentially more effective treatment option for this challenging condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* consecutive subjects with CPA who have received 12 months therapy with oral itraconazole

Exclusion Criteria:

(i) failure to provide informed consent; (ii) patients on immunosuppressive drugs, intake of \>10 mg prednisolone (or equivalent) for at least 3 weeks in last 3 months, or a diagnosis of human immunodeficiency virus syndrome, ; (iii) subjects with active pulmonary infection due to mycobacterium tuberculosis or mycobacteria other than tuberculosis (MOTT); (iv) subjects with others forms of pulmonary aspergillosis (subacute and acute invasive aspergillosis); (v) pregnancy.

Where it's running

• Chest clinic
  Chandigarh, Chandigarh, India Recruiting

Study contacts

• Study coordinator: Inderpaul S Sehgal, MD, DM
• Email: inderpgi@outlook.com
• Phone: 91-172-2756823

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.