Comparing nasal irrigation with azelastine and mometasone to nasal sprays for chronic rhinitis
Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis
This study is testing if a new way of cleaning the nose with special solutions works better than regular nasal sprays for people with chronic rhinitis.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 81 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Endeavor Health Academic / other |
| Locations | 1 site (Evanston, Illinois) |
| Trial ID | NCT05626621 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of high volume, high pressure nasal irrigation using azelastine and mometasone compared to standard nasal sprays in treating chronic rhinitis. Participants will be randomly assigned to one of three treatment regimens over a six-month period, with follow-up visits to assess symptom improvement and nasal health. The study seeks to determine if the irrigation method provides better clinical outcomes than traditional spray delivery. This research is significant as chronic rhinitis requires long-term management, and optimizing treatment methods could enhance patient quality of life.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older diagnosed with chronic rhinitis who are willing to undergo six months of topical therapy.
Not a fit: Patients with other nasal conditions that could explain their symptoms or those who are smokers may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective treatment options for patients suffering from chronic rhinitis.
How similar studies have performed: Prior studies have suggested that nasal irrigation may be more effective than sprays for certain medications, but this specific combination is being tested for the first time.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults 18 years and older seeking treatment for chronic rhinitis and willing to undergo six months of topical therapy. * Diagnosis of Chronic Rhinitis. Exclusion Criteria: * The patient has diagnosis(es) other than chronic rhinitis that can account for his/her symptoms (septal deviation, nasal valve collapse, chronic sinusitis). * Use of oral antihistamines or oral steroids, unless patient undergoes a 4 week washout period. * Smokers (tobacco, marijuana, vaping, etc.). * Known or suspected pregnancy, or lactation. * Other medical conditions that the investigator believed would confound the study. * Allergy to study drugs.
Where this trial is running
Evanston, Illinois
- Northshore University HealthSystem — Evanston, Illinois, United States (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.