Comparing nasal high flow oxygen therapy and non-invasive ventilation in healthy volunteers

Comparative Study of the Physiological Effects of High Flow Nasal Cannula and Non-invasive Ventilation in Healthy Volunteers

This study tests whether nasal high flow oxygen therapy works better than non-invasive ventilation for helping people breathe easier, using healthy volunteers to gather information for future treatments.

Quick facts

• Study type: Observational
• Enrollment: 10 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Unity Health Toronto (Academic / other)
• Locations: 1 site (Toronto, Ontario)
• Trial ID: NCT03902639 on ClinicalTrials.gov

What this trial studies

This study examines the effects of nasal high flow oxygen therapy compared to non-invasive ventilation techniques in healthy volunteers. It aims to assess how these methods influence oxygenation and the effort required for breathing. By utilizing healthy participants, the study seeks to gather data that could inform future treatments for patients experiencing respiratory failure. The research focuses on understanding the benefits and limitations of high-flow nasal cannula oxygen therapy versus traditional non-invasive ventilation methods.

Who should consider this trial

Good fit: Ideal candidates for this study are healthy volunteers aged 18 and older without any acute or chronic cardiopulmonary diseases.

Not a fit: Patients with active respiratory illnesses, significant nasal issues, or other specified exclusions may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide insights into more effective oxygenation techniques that may reduce the need for mechanical ventilation in patients with respiratory failure.

How similar studies have performed: Other studies have shown promising results with high-flow nasal cannula therapy, indicating potential benefits in respiratory management, although this specific comparison is less commonly explored.

Eligibility criteria

Inclusion Criteria:

* Healthy volunteers ≥ 18 y-o,
* No evidence of acute or chronic cardiopulmonary disease

Exclusion Criteria:

* Active epistaxis, sinus problem, nasal trauma, or deviated septum that would preclude the nasopharyngeal catheter insertion,
* Pregnancy, clinical evidence of respiratory illness, history of respiratory disease, body mass of over 50 kg/m2, ribcage malformation,
* Cardiac pace maker or implantable cardioverter-defibrillator according to EIT manufacturer,
* Allergy to topical lidocaine,
* Claustrophobia that would preclude the use of CPAP or HFNC.

Where this trial is running

Toronto, Ontario

• St. Michael's Hospital — Toronto, Ontario, Canada (Recruiting)

Study contacts

• Principal investigator: Laurent Brochard, MD — Unity Health Toronto
• Study coordinator: Laurent Brochard, MD

Conditions Healthy Volunteers; High flow nasal cannula; Airway pressure; Lung volume; Non-invasive ventilation