Comparing muscle protein synthesis from whole grain versus refined corn bread
Nutrient Profile and Muscle Protein Synthesis in Response to Corn Bread Made From Refined Versus Whole Grain Maize Flour
This study tests if eating whole grain corn bread instead of refined corn bread helps improve muscle health and nutrition in people.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 30 Years |
| Sex | All |
| Sponsor | University of California, Davis Academic / other |
| Locations | 1 site (Sacramento, California) |
| Trial ID | NCT06662214 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effects of consuming traditional East African corn bread made from either whole grain or refined maize flour on serum nutrient and hormonal profiles, as well as muscle protein synthesis rates. Participants will consume isonitrogenous portions of mung bean stew paired with the corn bread, and their post-prandial responses will be measured over three hours. Additionally, the study will compare the activation of muscle protein synthesis in an in vitro model using these two types of maize flour. The research focuses on understanding how different maize flour types impact muscle health and nutrition.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy, active males and females aged 18-30 with a normal weight.
Not a fit: Patients with dietary restrictions, food allergies to corn, or those who are overweight or have metabolic disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into dietary choices that enhance muscle protein synthesis and overall health for individuals relying on maize as a staple food.
How similar studies have performed: While studies on protein synthesis and dietary impacts exist, this specific comparison of whole grain versus refined maize flour in an East African context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy active males and females (To be considered active, volunteers must meet the following American College of Sports Medicine's guideline for physical activity for healthy adults: performing at least 150 minutes per week of moderate-to-vigorous intensity physical activity. * Age18-30 years * Normal weight (BMI between 18 and 25 kg/m2 Exclusion Criteria: * Health or dietary restrictions that would prevent consumption of the test foods * Known food allergy to corn * Anemia (low red blood cell count) * Overweight or obesity (BMI \> 25 kg/m2) * Receiving any medication that may interfere with the study * Metabolic or endocrine disorder that would affect the digestion, absorption, and/or physiological response to any of the nutrients ingested. * Currently not meeting the ACSM physical activity recommendations (IPAQ score \< 150 min/week of moderate-to-vigorous physical activity. * Pregnancy
Where this trial is running
Sacramento, California
- UC Davis CTSC Clinical Research Center — Sacramento, California, United States (Recruiting)
Study contacts
- Principal investigator: Keith Baar — University of California, Davis
- Study coordinator: Emelie Strandberg, PhD
- Email: ekstrandberg@ucdavis.edu
- Phone: 5307049253
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.