Comparing MRI and PET scans for liver cancer diagnosis
Official title: A Head-to-head Comparison of MRI, CT, 18F-FDGal and 18F-choline in Patients With Hepatocellular Carcinoma
Run by University of Aarhus · NCT05359939 · Data updated 2026-11-12
This study tests whether MRI or two types of PET scans are better at finding small liver cancer spots in patients with liver cirrhosis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University of Aarhus Academic / other |
| Locations | 1 site (Aarhus) |
| Status | Recruiting |
| Started | January 16, 2023 |
| Main results expected | December 2025 |
| Study ends | December 2025 |
| Registry record updated | December 20, 2024 |
| Trial ID | NCT05359939 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old diagnosed with hepatocellular carcinoma.
✕Probably not a fit
Patients who have contraindications for MRI or PET scans, such as severe renal insufficiency or claustrophobia, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study compares the effectiveness of MRI and two types of PET scans (using 18F-FDGal and 18F-choline) in diagnosing hepatocellular carcinoma (HCC), a common and aggressive liver cancer. The research aims to determine which imaging technique provides better sensitivity for detecting small lesions in patients with HCC, particularly those with underlying liver cirrhosis. By evaluating these imaging modalities, the study seeks to improve diagnostic accuracy and patient outcomes in HCC management.
Why it matters
Potential benefit: If successful, this study could lead to more accurate and earlier diagnosis of hepatocellular carcinoma, potentially improving treatment outcomes for patients.
How similar studies have gone: Previous studies have shown promising results in using advanced imaging techniques for cancer diagnosis, suggesting that this approach may yield beneficial outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients with hepatocellular carcinoma * age above 18 years Exclusion Criteria: * the patient does not want to take part in the study * the responsible investigator determines that the patient is not qualified for a PET scan * a history of moderate or intense hypersensitivity to a gadolinium-based contrast agent * renal insufficiency (estimated glomerular filtration rate \[eGFR\] \<30 ml/min/1.73 m2 body surface area * contraindications for MRI including claustrophobia * pregnant or nursing patients.
Where it's running
-
Aarhus University Hospital
Aarhus, Denmark Recruiting
Study contacts
- Study coordinator: Mona Kristiansen, MD
- Email: mkk@clin.au.dk
- Phone: +4527491598
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.