Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Comparing MRI and PET scans for liver cancer diagnosis

Official title: A Head-to-head Comparison of MRI, CT, 18F-FDGal and 18F-choline in Patients With Hepatocellular Carcinoma

Run by University of Aarhus · NCT05359939 · Data updated 2026-11-12

This study tests whether MRI or two types of PET scans are better at finding small liver cancer spots in patients with liver cirrhosis.

More Hepatocellular Carcinoma trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment50 (estimated)
SponsorUniversity of Aarhus
Academic / other
Locations1 site (Aarhus)
StatusRecruiting
StartedJanuary 16, 2023
Main results expectedDecember 2025
Study endsDecember 2025
Registry record updatedDecember 20, 2024
Trial IDNCT05359939 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults over 18 years old diagnosed with hepatocellular carcinoma.

Probably not a fit

Patients who have contraindications for MRI or PET scans, such as severe renal insufficiency or claustrophobia, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares the effectiveness of MRI and two types of PET scans (using 18F-FDGal and 18F-choline) in diagnosing hepatocellular carcinoma (HCC), a common and aggressive liver cancer. The research aims to determine which imaging technique provides better sensitivity for detecting small lesions in patients with HCC, particularly those with underlying liver cirrhosis. By evaluating these imaging modalities, the study seeks to improve diagnostic accuracy and patient outcomes in HCC management.

Why it matters

Potential benefit: If successful, this study could lead to more accurate and earlier diagnosis of hepatocellular carcinoma, potentially improving treatment outcomes for patients.

How similar studies have gone: Previous studies have shown promising results in using advanced imaging techniques for cancer diagnosis, suggesting that this approach may yield beneficial outcomes.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* patients with hepatocellular carcinoma
* age above 18 years

Exclusion Criteria:

* the patient does not want to take part in the study
* the responsible investigator determines that the patient is not qualified for a PET scan
* a history of moderate or intense hypersensitivity to a gadolinium-based contrast agent
* renal insufficiency (estimated glomerular filtration rate \[eGFR\] \<30 ml/min/1.73 m2 body surface area
* contraindications for MRI including claustrophobia
* pregnant or nursing patients.

Where it's running

  • Aarhus University Hospital
    Aarhus, Denmark
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  • Zinc add-on with targeted therapy plus immunotherapy for advanced liver cancer

    This study tests whether adding daily zinc to standard targeted therapy and immunotherapy helps people with unresectable or advanced hepatocellular carcinoma.

    Recruiting Phase 2 Anhui Provincial Hospital · Hefei, Anhui · NCT07793695

  • 68Ga-SorB PET/CT imaging for solid tumors

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  • Hepatocellular Carcinoma Patient Registry (CHARM Hepatocellular Carcinoma MEA)

    This observational study collects medical records of adults with hepatocellular carcinoma to understand how the disease presents and progresses across regions in the Middle East and North Africa.

    Recruiting AstraZeneca · Al Mansurah and 16 other locations · NCT07650773

  • GLP-1 RA plus standard treatment in first-line metastatic GI cancers

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.