Comparing MRI and CT for liver assessment in rectal cancer patients
Official title: Limerick - Liver Magnetic Resonance Imaging Before Treatment for Rectal Cancer. A Randomised Controlled Trial.
Run by Vastra Gotaland Region · NCT05215535 · Data updated 2026-11-12
This study tests if a shorter MRI can give the same useful information as a special CT scan for checking the liver in patients with rectal cancer before they start treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Vastra Gotaland Region Government |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Gothenburg) |
| Status | Recruiting |
| Started | April 12, 2022 |
| Main results expected | December 2027 |
| Study ends | December 2029 |
| Registry record updated | August 19, 2024 |
| Trial ID | NCT05215535 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 years old who have been clinically or endoscopically diagnosed with suspected rectal cancer and are eligible for further radiological investigation.
✕Probably not a fit
Patients who may not benefit include those unable to undergo MRI due to claustrophobia or medical implants, as well as those diagnosed with benign rectal diseases or recurrent rectal cancer.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicentre randomized controlled trial investigates the effectiveness of an abbreviated MRI compared to a combined single venous phase CT with an additional 3-minute equilibrium phase for liver assessment in patients diagnosed with rectal cancer. The study aims to determine if the abbreviated MRI can provide comparable results in the pretreatment radiological workup, which is crucial for planning treatment strategies. By focusing on tumor characteristics and patient factors, the trial seeks to enhance the accuracy of local staging and metastasis evaluation in rectal cancer patients.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy and treatment planning for patients with rectal cancer.
How similar studies have gone: Previous studies have shown that MRI is superior to CT for liver assessment, suggesting that this approach may yield beneficial results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults \>18 years of age * Endoscopically or clinically diagnosed with (suspected) rectal cancer and considered for further radiological investigation * Are able to understand trial information and provide oral and written consent Exclusion Criteria: * Patients unable to undergo MRI (causes may include claustrophobia, presence of pacemaker or certain metal components in their body). * Patients diagnosed with benign disease of the rectum or squamous cell carcinoma * Patients diagnosed with recurrent rectal cancer * Patients unable to understand the trial information
Where it's running
-
Sahlgrenska University Hospital/Östra
Gothenburg, Sweden Recruiting
Study contacts
- Principal investigator: Jennifer Park, MD, PhD — Sahlgrenska University Hospital, Sahlgrenska Academy, Gothenburg Sweden
- Study coordinator: Jennifer Park, MD, PhD
- Email: jennifer.park@vgregion.se
- Phone: +46-31-3436780
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.