Comparing MRI and CT for diagnosing coronary artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the diagnostic accuracy of cardiovascular magnetic resonance (CMR) and computed tomography with fractional flow reserve (CT-FFR) in patients suspected of having coronary artery disease (CAD). It aims to determine how well these imaging techniques perform compared to invasive fractional flow reserve (FFR), which serves as the reference standard. The study will involve 300 patients referred for invasive coronary angiography, with a subset undergoing additional CMR scans for comparison. The goal is to improve the specificity and positive predictive value of CAD diagnosis, potentially reducing unnecessary invasive procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged ≥18 years
* Referred for invasive coronary angiography for investigation of chest pain

Exclusion Criteria:

* Recent acute coronary syndrome (\< 6 months)
* Previous coronary artery bypass grafting
* Severe claustrophobia
* Absolute contraindications to CMR - those with MR conditional or safe devices will be included
* Second-/third-degree atrioventricular block
* Severe chronic obstructive pulmonary disease
* Moderate-severe asthma
* Estimated glomerular filtration rate \<30 ml/min/1.73m2
* Women who are pregnant, breast-feeding or of child-bearing potential( premenopausal women)
* Contraindication to iodinated contrast
* Participation in a research study involving an investigational product in the past 12 weeks

Where it's running

• Glenfield Hospital
  Leicester, Leics, United Kingdom Recruiting

Study contacts

• Study coordinator: Jayanth Arnold
• Email: jra14@le.ac.uk
• Phone: 0300 303 1573

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.