Comparing MRI and CT for diagnosing coronary artery disease
Comparison of Cardiovascular Magnetic Resonance and Computed Tomography With Fractional Flow Reserve in the Diagnosis of Suspected Coronary Artery Disease
This study is testing whether MRI or CT scans can better diagnose coronary artery disease in patients who might need invasive heart procedures.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Leicester Academic / other |
| Locations | 1 site (Leicester, Leics) |
| Trial ID | NCT04761991 on ClinicalTrials.gov |
What this trial studies
This observational study evaluates the diagnostic accuracy of cardiovascular magnetic resonance (CMR) and computed tomography with fractional flow reserve (CT-FFR) in patients suspected of having coronary artery disease (CAD). It aims to determine how well these imaging techniques perform compared to invasive fractional flow reserve (FFR), which serves as the reference standard. The study will involve 300 patients referred for invasive coronary angiography, with a subset undergoing additional CMR scans for comparison. The goal is to improve the specificity and positive predictive value of CAD diagnosis, potentially reducing unnecessary invasive procedures.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are referred for invasive coronary angiography due to suspected coronary artery disease.
Not a fit: Patients with recent acute coronary syndrome, severe claustrophobia, or contraindications to CMR or iodinated contrast may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate non-invasive diagnostic methods for coronary artery disease, reducing the need for invasive angiography.
How similar studies have performed: Other studies have shown promising results with similar imaging approaches, indicating potential for success in this study.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged ≥18 years * Referred for invasive coronary angiography for investigation of chest pain Exclusion Criteria: * Recent acute coronary syndrome (\< 6 months) * Previous coronary artery bypass grafting * Severe claustrophobia * Absolute contraindications to CMR - those with MR conditional or safe devices will be included * Second-/third-degree atrioventricular block * Severe chronic obstructive pulmonary disease * Moderate-severe asthma * Estimated glomerular filtration rate \<30 ml/min/1.73m2 * Women who are pregnant, breast-feeding or of child-bearing potential( premenopausal women) * Contraindication to iodinated contrast * Participation in a research study involving an investigational product in the past 12 weeks
Where this trial is running
Leicester, Leics
- Glenfield Hospital — Leicester, Leics, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Jayanth Arnold
- Email: jra14@le.ac.uk
- Phone: 0300 303 1573
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.