Comparing molecular and conventional methods for diagnosing infections in lung transplant patients
Comparison Between Rapid Molecular Technique BioFire Pneumonia Panel Filmarray and Conventional Culture-based Methods in the Microbiologic Diagnosis on Bronchoalveolar Lavage Fluid of Lung Transplant Patients
This study is testing a new quick method for finding infections in lung transplant patients to see if it works better than the usual way.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 53 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Academic / other |
| Locations | 1 site (Milano) |
| Trial ID | NCT05960383 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of the BioFire Pneumonia Panel, a rapid molecular diagnostic technique, against traditional culture-based methods for identifying infections in lung transplant patients. It involves collecting bronchoalveolar lavage samples from both lung donors and recipients to assess microbiological concordance and resistance patterns. The study will also measure the time taken to obtain microbiological results and make clinical decisions based on these diagnostics. Conducted at IRCCS Fondazione Cà Granda Policlinico in Milan, the study includes patients over 18 years undergoing lung transplantation.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years who are scheduled to undergo lung transplantation.
Not a fit: Patients who do not meet the inclusion criteria for lung transplantation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to faster and more accurate diagnosis of infections in lung transplant patients, improving patient outcomes.
How similar studies have performed: While molecular diagnostics have shown promise in other settings, this specific application in lung transplantation is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * all patients aged \>18 years that undergo lung transplantation from February 2023, at IRCCS Fondazione Cà Granda Policlinico in Milan and performed FBS+BAL Exclusion Criteria: * Patients who do not meet inclusion criteria are excluded from this study.
Where this trial is running
Milano
- Irccs Fondazione Ca' Granda Policlinico Di Milano — Milano, Italy (Recruiting)
Study contacts
- Study coordinator: Valeria Pastore
- Email: valeria.pastore@policlinico.mi.it
- Phone: 00390255034770
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.