Comparing modified deep extubation to standard awake extubation
Official title: A Comparison of a Modified Deep Extubation to Standard Awake Extubation for Decreasing Operating Room Time: a Randomized Controlled Trial
Run by Samuel Lunenfeld Research Institute, Mount Sinai Hospital · NCT06318715 · Data updated 2026-11-12
This study is testing if a new way of waking patients up after laparoscopic surgery can help them leave the operating room faster than the usual method.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Samuel Lunenfeld Research Institute, Mount Sinai Hospital Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Status | Recruiting |
| Started | April 8, 2024 |
| Main results expected | December 30, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | October 28, 2026 |
| Trial ID | NCT06318715 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are ASA I-III patients scheduled for elective laparoscopic surgery under general anesthesia.
✕Probably not a fit
Patients who are high-risk, such as those with a documented difficult airway or those requiring emergency surgery, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study compares two extubation techniques for low-risk patients undergoing laparoscopic surgery under general anesthesia: modified deep extubation (mDE) and standard awake extubation (AE). The mDE technique involves extubation while the patient is still anesthetized but with a lower dose of anesthetic gas, balanced with long-acting opioids to minimize airway reactions. The goal is to determine if mDE can reduce the time from the end of surgery to when the patient is ready to leave the operating room by at least 5 minutes compared to standard AE. Patients will be selected based on specific inclusion and exclusion criteria during their pre-admission assessment.
Why it matters
Potential benefit: If successful, this approach could lead to faster recovery times for patients after laparoscopic surgery.
How similar studies have gone: Previous studies have indicated that modified deep extubation techniques can be as safe as standard awake extubation, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA I-III * laparoscopic surgery under general anesthesia Exclusion Criteria: * High-risk patients: * Documented difficult airway during intubation or developed intraoperatively. * Full stomach * Pregnant women * Emergency surgery * BMI\>30 * Intraoperative bleeding leading to transfusion * Use of remifentanil during extubation * Requirement for prone position for surgical approach (i.e., spine surgery, anal fistulectomy, tumor resection of the back, etc) * Absolute indication for awake or deep extubation * Use of opioids in chronic pain patients
Where it's running
-
Department of Anesthesia Mount Sinai Hospital
Toronto, Ontario, Canada Recruiting
Study contacts
- Study coordinator: naveed siddiqui, MD
- Email: naveed.siddiqui@uhn.ca
- Phone: 416-586-5270
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.