Comparing mifepristone and misoprostol for cervical preparation in abortions
Official title: Mifepristone Versus Misoprostol for Cervical Preparation Prior to Procedural Abortion at 12 to 16 Weeks' Gestation in an Academic Medical Center: a Randomized Controlled Pilot Trial
Run by Montefiore Medical Center · NCT06502158 · Data updated 2026-11-12
This study tests whether mifepristone or misoprostol is better for preparing the cervix in people having abortions between 12 to 16 weeks of pregnancy.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 94 (estimated) |
| Sponsor | Montefiore Medical Center Academic / other |
| Locations | 1 site (The Bronx, New York) |
| Status | Recruiting |
| Started | October 31, 2024 |
| Main results expected | June 2027 |
| Study ends | June 2027 |
| Registry record updated | July 24, 2026 |
| Trial ID | NCT06502158 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are English or Spanish-speaking individuals seeking an induced abortion of a singleton pregnancy between 12 weeks and 16 weeks gestation.
✕Probably not a fit
Patients with a history of multiple Cesarean deliveries, certain placental conditions, or significant obesity may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to compare the effectiveness of mifepristone versus misoprostol for cervical preparation in patients undergoing procedural abortions between 12 to 16 weeks of gestation. The study will randomly assign participants to receive either mifepristone or misoprostol and assess the success rate of cervical dilation in each group. Given the importance of cervical preparation in reducing surgical complications, this trial seeks to identify the most effective and patient-friendly option for this critical procedure. The findings could influence clinical practices and improve patient experiences during abortion care.
Why it matters
Potential benefit: If successful, this study could lead to improved cervical preparation methods, enhancing safety and comfort for patients undergoing procedural abortions.
How similar studies have gone: Previous studies have shown mifepristone's efficacy as a cervical ripening agent, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * English or Spanish-speaking * Capacity to consent * Seeking induced abortion of a singleton pregnancy between 12 weeks, 0 days and 16 weeks, 6 days (based on age at day of surgery) Exclusion Criteria: * History of more than two prior Cesarean deliveries * Sonographic evidence of placenta previa * Sonographic concern for morbidly adherent placenta * Prior obstetric hemorrhage requiring transfusion * Obstructive cervical or lower uterine segment fibroid * Current therapeutic anticoagulation use * Cerclage in situ * History of more than one prior cervical excisional procedure * BMI greater than 50 kg/m\^2
Where it's running
-
Montefiore Medical Center
The Bronx, New York, United States Recruiting
Study contacts
- Principal investigator: Antoinette Danvers, MD, MSCR, MBA — Montefiore Medical Center
- Study coordinator: Laura Fletcher, MD, MPH
- Email: lfletcher@montefiore.org
- Phone: 516-587-3297
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.