Comparing microwave ablation and liver surgery for treating intrahepatic cholangiocarcinoma
Official title: Microwave Ablation Versus Liver Resection for Intrahepatic Cholangiocarcinoma Within Milan Criteria
Run by Chinese PLA General Hospital · NCT06462742 · Data updated 2026-11-12
This study is testing whether microwave ablation can be a good first treatment option for people with a specific type of liver cancer compared to traditional liver surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Chinese PLA General Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | January 1, 2009 |
| Main results expected | June 1, 2029 |
| Study ends | June 1, 2029 |
| Registry record updated | July 25, 2024 |
| Trial ID | NCT06462742 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with pathologically diagnosed iCCA who meet the Milan criteria for treatment.
✕Probably not a fit
Patients with tumors that exceed the Milan criteria or those with other malignancies may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the effectiveness of microwave ablation (MWA) compared to liver resection (LR) in patients with intrahepatic cholangiocarcinoma (iCCA). It will analyze survival outcomes and identify risk factors associated with both treatment methods. Data will be collected from multiple hospitals for patients who meet specific criteria, focusing on those with tumors within the Milan criteria. The study seeks to determine if MWA can serve as a viable first-line treatment option for iCCA.
Why it matters
Potential benefit: If successful, this study could provide an alternative treatment option for patients with iCCA, potentially improving survival rates.
How similar studies have gone: While thermal ablation has been established for hepatocellular carcinoma, evidence for its efficacy in iCCA is limited, making this approach relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. pathologically diagnosed iCCA based on the WHO classifications; 2. curative-intent liver resection or microwave ablation; 3. tumor within Milan criteria, namely single tumor ≤5cm in maximum diameter; multiple tumors ≤3 in number and each ≤3cm; no evidence of major vascular/hilar invasion, extrahepatic/lymphatic metastasis or other malignancies; 4. age ≥18 years. Exclusion Criteria: Patients not meeting any one of the inclusion criteria were excluded.
Where it's running
-
Chinese PLA General Hospital
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: Chuan Pang, Doctor
- Email: pcpang117@163.com
- Phone: +86-18910527022
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.