Clinical trial Recruiting at 1 site Observational Ages 18 and up

Comparing microwave ablation and liver surgery for treating intrahepatic cholangiocarcinoma

Official title: Microwave Ablation Versus Liver Resection for Intrahepatic Cholangiocarcinoma Within Milan Criteria

Run by Chinese PLA General Hospital · NCT06462742 · Data updated 2026-11-12

This study is testing whether microwave ablation can be a good first treatment option for people with a specific type of liver cancer compared to traditional liver surgery.

More Overall Survival trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment1000 (estimated)
SponsorChinese PLA General Hospital
Academic / other
Locations1 site (Beijing, Beijing Municipality)
StatusRecruiting
StartedJanuary 1, 2009
Main results expectedJune 1, 2029
Study endsJune 1, 2029
Registry record updatedJuly 25, 2024
Trial IDNCT06462742 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older with pathologically diagnosed iCCA who meet the Milan criteria for treatment.

Probably not a fit

Patients with tumors that exceed the Milan criteria or those with other malignancies may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the effectiveness of microwave ablation (MWA) compared to liver resection (LR) in patients with intrahepatic cholangiocarcinoma (iCCA). It will analyze survival outcomes and identify risk factors associated with both treatment methods. Data will be collected from multiple hospitals for patients who meet specific criteria, focusing on those with tumors within the Milan criteria. The study seeks to determine if MWA can serve as a viable first-line treatment option for iCCA.

Why it matters

Potential benefit: If successful, this study could provide an alternative treatment option for patients with iCCA, potentially improving survival rates.

How similar studies have gone: While thermal ablation has been established for hepatocellular carcinoma, evidence for its efficacy in iCCA is limited, making this approach relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. pathologically diagnosed iCCA based on the WHO classifications;
2. curative-intent liver resection or microwave ablation;
3. tumor within Milan criteria, namely single tumor ≤5cm in maximum diameter; multiple tumors ≤3 in number and each ≤3cm; no evidence of major vascular/hilar invasion, extrahepatic/lymphatic metastasis or other malignancies;
4. age ≥18 years.

Exclusion Criteria:

Patients not meeting any one of the inclusion criteria were excluded.

Where it's running

  • Chinese PLA General Hospital
    Beijing, Beijing Municipality, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.