Comparing micro-ultrasound and MRI for monitoring prostate cancer
Micro-UltraSound In Cancer - Active Surveillance (MUSIC-AS)
NA · University of Alberta · NCT05558241
This study is testing whether micro-ultrasound or MRI is better at tracking prostate cancer in men with low-grade disease to see if it helps catch any changes sooner.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 210 (estimated) |
| Ages | 18 Years and up |
| Sex | Male |
| Sponsor | University of Alberta (other) |
| Locations | 5 sites (Los Angeles, California and 4 other locations) |
| Trial ID | NCT05558241 on ClinicalTrials.gov |
What this trial studies
This study compares the effectiveness of micro-ultrasound and MRI in monitoring prostate cancer during active surveillance. Participants with Gleason Grade Group 1 prostate cancer will undergo targeted biopsies using both imaging modalities to assess the detection of clinically significant cancer. The study aims to determine which imaging method is more effective in identifying progression to higher-grade prostate cancer. Additionally, blood samples will be collected for future biomarker research.
Who should consider this trial
Good fit: Ideal candidates are adult men with Gleason Grade Group 1 prostate cancer who are currently under active surveillance and require a confirmatory biopsy.
Not a fit: Patients who cannot undergo MRI or biopsy will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the accuracy of prostate cancer monitoring, leading to better patient outcomes.
How similar studies have performed: Other studies have shown promising results using micro-ultrasound for prostate cancer detection, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult men with Gleason Grade Group 1 prostate cancer managed by active surveillance who require a confirmatory prostate biopsy Exclusion Criteria: * Men who cannot undergo a prostate MRI * Men who cannot undergo a prostate biopsy
Where this trial is running
Los Angeles, California and 4 other locations
- University of California Los Angeles, Department of Urology — Los Angeles, California, United States (RECRUITING)
- Kipnes Urology Centre - Kaye Edmonton Clinic — Edmonton, Alberta, Canada (RECRUITING)
- University of British Columbia — Vancouver, Alberta, Canada (RECRUITING)
- CIUSSS du Nord-de-L'Ile-De-Montreal — Montreal, Quebec, Canada (RECRUITING)
- Humanitas — Milan, Italy (RECRUITING)
Study contacts
- Principal investigator: Adam Kinnaird, MD, PhD — University of Alberta
- Study coordinator: Adam Kinnaird, MD, PhD
- Email: ask@ualberta.ca
- Phone: 780-407-5800
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Prostate Cancer, Active surveillance, micro-ultrasound