Comparing methods to predict weaning success in patients with lung congestion

Thoracic Fluid Content by Electrical Cardiometry Versus Diaphragmatic Excursion by Ultrasound for Prediction of Weaning Success in Patients With Lung Congestion

This study tests two ways to see which one better predicts if patients with lung congestion can successfully stop using a ventilator.

Quick facts

• Study type: Observational
• Enrollment: 100 (estimated)
• Ages: 18 Years to 70 Years
• Sex: All
• Sponsor: Benha University (Academic / other)
• Locations: 1 site (Cairo)
• Trial ID: NCT05947942 on ClinicalTrials.gov

What this trial studies

This study compares two methods for predicting the success of weaning patients from ventilatory support who have lung congestion. It evaluates thoracic fluid content measured by electrical cardiometry against diaphragmatic excursion measured by ultrasound. The study focuses on patients with conditions such as COPD exacerbations, pneumonia, and heart failure, who are candidates for weaning from mechanical ventilation. By assessing these parameters, the study aims to improve the weaning process and patient outcomes.

Who should consider this trial

Good fit: Ideal candidates are patients aged 18-70 with lung congestion who are being considered for weaning from invasive mechanical ventilation.

Not a fit: Patients outside the age range of 18-70, those with obesity, or those with specific respiratory or cardiac conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to more effective weaning strategies for patients with lung congestion, potentially reducing ventilator dependency and improving recovery times.

How similar studies have performed: While this approach is innovative, similar studies have not been widely reported, indicating that this may be a novel investigation.

Eligibility criteria

Inclusion Criteria:

* • Patients of both genders aged 18-70 years old.

  * Acute Physiology and Chronic Health Evaluation II (APACHE II) score
  * Patients with congested lung including; Acute exacerbation of COPD patients with acute respiratory failure (PaO2/FiO2 ratio ≤300 or PaCO2 ≥ 50 mm Hg at intubation), pneumonia, chronic kidney disease, heart failure (New York Heart Association Classification III, IV) who will be candidate for weaning from invasive mechanical ventilation according to the treating physician's judgement using the ICU weaning protocol.

Exclusion Criteria:

* • Patients younger than 18 years or older than 70 years

  * Refusal to participate.
  * Obesity (BMI≥35).
  * Pregnancy.
  * Patients with pneumothorax, pleural, or pericardial effusion, lung contusion, and thoracotomy.
  * Hepatic dysfunction.
  * history or new detection of paralysis (no movement) or paradoxical movement of a single hemidiaphragm.
  * preexisting cervical spinal injury, history of neuromuscular disorders
  * Patients with injuries, burns, or wounds which precluded the proper application of the device electrodes will be also excluded from the study.
  * Mechanical ventilation \< 48 hrs

Where this trial is running

Cairo

• Shawky meselhi shawky — Cairo, Egypt (Recruiting)

Study contacts

• Study coordinator: Shawky Elshaer

Conditions Lung; Congestive