Comparing methods to predict gastric cancer risk
Performance of Endoscopic and Histological Criteria of Atrophic Gastritis and Intestinal Metaplasia in Predicting Risk of Gastric Cancer - a Multicenter Case Control Study
This study is testing different ways to predict the risk of developing gastric cancer in patients with stomach issues compared to those without any problems.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 40 Years and up |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 4 sites (Hong Kong and 3 other locations) |
| Trial ID | NCT04184960 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate different risk stratification models for predicting gastric cancer development by comparing endoscopic and histological assessments. It will involve a multi-center approach, recruiting patients with gastric neoplasia and a control group without prior gastric issues. The study will utilize criteria such as atrophic gastritis and intestinal metaplasia to assess risk factors through gastroscopy and gastric biopsies.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 40 and above who are undergoing elective upper gastrointestinal endoscopy.
Not a fit: Patients with a history of gastrectomy or severe coagulopathy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate predictions of gastric cancer risk, allowing for earlier interventions.
How similar studies have performed: Other studies have shown promise in using similar assessment methods for gastric cancer risk prediction, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Two groups of patients would be recruited in this case control study. 1. Gastric neoplasia group Patients with newly diagnosed or history of cancer of stomach or gastric high grade dysplasia. 2. Control group Patients with no prior history of gastric dysplasia or cancer Inclusion criteria: 1. Age 40 or above 2. Undergo elective upper gastrointestinal endoscopy Exclusion criteria: 1. Patients with history of gastrectomy 2. Patients with severe thrombocytopenia (Platelet count \<50) or coagulopathy (INR \> 1.5 or on anticoagulation) 3. Contraindication to upper gastrointestinal endoscopy 4. Allergy towards sedative agents (Midazolam / Diazepam) or local anaesthetic spray (Lignocaine) 5. Patients who cannot give informed consent
Where this trial is running
Hong Kong and 3 other locations
- Prince of Wales Hospital — Hong Kong, Hong Kong (Recruiting)
- Osaka International Cancer Institute — Osaka, Japan (Not_yet_recruiting)
- Changi General Hospital — Singapore, Singapore (Not_yet_recruiting)
- King Chulalongkorn Memorial Hospital and Chulalongkorn University — Bangkok, Thailand (Not_yet_recruiting)
Study contacts
- Principal investigator: Hon Chi Yip — Chinese University of Hong Kong
- Study coordinator: Hon Chi Yip, FRCSEd(Gen)
- Email: hcyip@surgery.cuhk.edu.hk
- Phone: +852 35052627
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.