Comparing methenamine and antibiotics to prevent urinary tract infections after mid-urethral sling surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of methenamine prophylaxis compared to traditional antibiotic prophylaxis in preventing urinary tract infections (UTIs) following mid-urethral sling (MUS) procedures for stress urinary incontinence (SUI). The study aims to address the high incidence of post-operative UTIs, which can occur in 21-34% of patients after MUS placement. By evaluating methenamine, a urinary antiseptic that does not contribute to antibiotic resistance, the trial seeks to promote antibiotic stewardship while ensuring patient safety. Participants will be female patients aged 18 and older undergoing MUS procedures, and they will receive either methenamine or antibiotics post-operatively.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Female
2. Age ≥ 18
3. Patients undergoing mid-urethral sling procedure

Exclusion Criteria:

1. Medication intolerance or allergy to study medications
2. Renal impairment with GFR \<30
3. Breast feeding
4. Pregnancy
5. Recurrent urinary tract infections
6. Active urinary tract infection
7. Immunosuppressive disease
8. Interstitial cystitis

Where it's running

• Atlantic Health
  Morristown, New Jersey, United States Recruiting

Study contacts

• Study coordinator: Rena Ow, MD
• Email: rena.ow@atlantichealth.org
• Phone: 9739717267

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Precision management of urinary tract symptoms in older women

  This trial tests three ways to treat urinary tract symptoms in women 65 and older to see which approach works best and minimizes unnecessary antibiotic use.

  Recruiting Phase 3 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07686055

• Hyperbaric oxygen for chronic radiation cystitis

  This project will try hyperbaric oxygen therapy in adults with moderate to severe radiation cystitis to see if symptoms improve and urine inflammatory markers change.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT07368647

• Intravesical Lactobacillus crispatus for urinary health in people with neurogenic bladder

  This study will test whether putting Lactobacillus crispatus into the bladder can help reduce urinary symptoms and urinary tract infections in adults with neurogenic lower urinary tract dysfunction who use intermittent catheters.

  Recruiting Early Phase 1 Medstar Health Research Institute · Washington D.C., District of Columbia · NCT07308808

• New care guideline for infants 60 days and younger with fever in Sweden

  This project will test a new guideline to see if infants 60 days or younger with fever can safely avoid many invasive tests, hospital stays, and broad antibiotics compared with usual care.

  Recruiting at 9 sites Region Skane · Gothenburg and 10 other locations · NCT07134751

• Investigating the link between urinary tract infections and preeclampsia in pregnant women

  This study is trying to see if having a urinary tract infection during pregnancy is linked to developing preeclampsia in pregnant women.

  Recruiting Pakistan Air Force (PAF) Hospital Islamabad · Islamabad · NCT06962644

• Methenamine Hippurate After BOTOX-A Injections for Overactive Bladder

  This study tests whether methenamine hippurate can prevent urinary infections after BOTOX-A injections in women with overactive bladder, compared with standard antibiotic prophylaxis.

  Recruiting Phase 4 Women and Infants Hospital of Rhode Island · Providence, Rhode Island · NCT06953271

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.